“I am indebted to Dr. (now Professor Sir Robert) Williams for bringing me into the team [The (British) PHLS Committee on Formaldehyde Disinfection] which investigated the use of formaldehyde for disinfecting fabrics. He gave me the job of finding a nontoxic neutralizing agent with which to treat infected fabric after exposure to formaldehyde vapour, in order that the bacterial viability results...

A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting materials as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used at room temperature under solvent-free condition for the Hantzsch pyridine synt...

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/...

Cholesterol is measured by mixing 5 mul of sample with 350 mul of a reagent consisting of phenol, 4-aminoantipyrine, and the enzymes cholesterol oxidase, cholesterol esterase, and peroxidase. After 12 min, the resulting quinoneimine is measured at 520 nm. Readings and cholesterol concentrations are linearly related up to 4.0 g/liter. Lipemic sera and samples containing uric acid (up to 200 mg/l...

A carbene-catalyzed reductive coupling reaction of carboxylic esters and substituted Hantzsch is disclosed. Key steps this include one-electron reduction a carbene catalyst-bound acyl azolium intermediate to generate the corresponding radical for subsequent alkylation reactions. The promoted by irradiation with visible light without involvement transition-metal photocatalysts. Mechanistic studi...

Polyaza-heterocycles show a plethora of biological properties and represent significant percentage clinically used drugs. However, the imizado[1,2-a]pyrimidine ring system needs more attention in terms pharmaceutical applications. Herein, we report sequence involving an aldolic condensation/bromination/Hantzsch reaction to construct series 2-alkenylimidazo[1,2-a]pyrimidines for exploring their ...