Mass spectrometry approaches to biomarker discovery in human fluids have received a great deal of attention in recent years. While mass spectrometry instrumentation and analysis approaches have been widely investigated, little attention has been paid to how sample handling can impact the plasma proteome and therefore influence biomarker discovery. We have investigated the effects of two main as...

MicroRNAs (miRs, miRNAs) play central roles in gene regulation. Previously, we reported that miRNAs from pasteurized, store-bought bovine milk have biological activity in humans. Here we assessed the effects of milk processing, storage, somatic cell content, and handling by consumers on the degradation of miRNAs in milk; we also quantified miRNAs in dairy products. Pasteurization and homogeniza...

0957-4174/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.eswa.2012.12.071 ⇑ Corresponding author. Tel.: +852 27666597; fax: E-mail addresses: [email protected] polyu.edu.hk (K.L. Choy), [email protected] polyu.edu.hk (C.K. Kwong), [email protected] (C. Due to the fact that wine is highly sensitive to storage conditions such as temperature and humidity, ...

The development and deployment of practical Semantic Web applications requires technologies for the storage and retrieval of RDF data that are robust and scalable. In this paper, we describe the 3store RDF storage and query engine developed within the Advanced Knowledge Technologies project, and discuss the design rationale and optimisations behind it which enable the efficient handling of larg...

We investigated the effects of handling and fixation processes on the two-photon fluorescence spectroscopy of endogenous fluorophors in mouse skeletal muscle. The skeletal muscle was handled in one of two ways: either sectioned without storage or sectioned following storage in a freezer. The two-photon fluorescence spectra measured for different storage or fixation periods show a differential a...

Prolonged storage of large quantities of bagasse for off-season power generation presents challenges different from those associated with small-scale storage or large-scale, wet storage for pulp and paper production. The challenges include loss of fuel value, spontaneous combustion, bagasse handling and a variety of health and environmental impacts. Experiences with these challenges in Australi...