BACKGROUND A large number of hand, foot and mouth disease (HFMD) outbreaks was reported during 2008 in China. However, little is known about the effects of meteorological conditions on different temporal and spatial scales on HFMD incidence in children. The aim of this study was to explore the relationship between meteorological data on various temporal and spatial scales and HFMD incidence amo...

1970年,北 海 道 にHand,foot and mouth disease の 大 き な流 行 の あつ た 際 に,Coxsackie A 16と こ の ウ イル ス 以外 にCoxsackie Aウ イ ル ス が分 離 され た. これ らの うち,帯 広,旭 川,札 幌 の3地 区 の 患者153 名 か ら,サ ル 腎 初 代 培 養 細 胞 に よつ てCoxsackie A 16 が79株(51.6%),未 同定 の ウイ ル ス が25株(16.3%) が分 離 され た. 一 方 ,同 一 被 検 体 を 哺 乳 マ ウス接 種 に よつ て,Coxsackie A 16が61株(39.9%)分 離 され た ほ か に,Coxsackie A4が17株(11.1%),A5が27株(17.6%),A6 が63株(41.2%),A10が9株(5.9%)が 分...

INTRODUCTION Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS A case control study was conducted in a designated hospita...

BACKGROUND Hand, foot and mouth disease (HFMD) has circulated in China and caused yearly outbreak. To understand the transmission of the disease and to assess the spatial variation in cases reported, we examined age-specific transmission characteristics and reporting rates of HFMD for 31 provinces in mainland China. METHODS We first analyzed incidence spatial patterns and age-specific inciden...

As part of an ongoing effort to generate complete genome sequences of hand, foot and mouth disease-causing enteroviruses directly from clinical specimens, two complete coding sequences and two partial genomic sequences of human bocavirus 1 (n=3) and 2 (n=1) were co-amplified and sequenced, representing the first genome sequences of human bocaviruses from Vietnam. The sequences may aid future st...

Hand, foot and mouth disease (HFMD) is one of the major public-health problems in China. Based on the HFMD data of the Department of Health of Shandong Province, we propose a dynamic model with periodic transmission rates to investigate the seasonal HFMD. After evaluating the basic reproduction number, we analyze the dynamical behaviors of the model and simulate the HFMD data of Shandong Provin...

Hand, foot and mouth disease (HFMD) has been a substantial burden throughout the Asia-Pacific countries over the past decades. For the purposes of disease prevention and climate change health impact assessment, it is important to understand the temperature-disease association for HFMD in different geographical locations. This study aims to assess the impact of temperature on HFMD incidence in a...

The experience of two Edinburgh practices during an outbreak of hand, foot and mouth disease in 1980 is described. Twenty-five cases were diagnosed, nearly all of them under the age of 10 years.