Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly...

The effect of Cotinine, active metabolite of nicotine, on Aβ1-42 neurotoxicity was investigated. Cotinine possesses a longer plasma half-life, lower toxicity and it is a partial agonist of the nicotinic acetylcholine receptors (nAChR). Cotinine prolonged the survival of cortical neurons exposed to Aβ1-42. These results indicated that cotinine has a neuroprotective effect by inhibition of the fo...

Background: The aim of this study was to evaluate protective effects of melatonin on uterus and fallopian tube in female mice under treatment with nicotine. Materials and Methods: Adult Female mice were divided into four groups. Group A: control animals received normal saline, group B: were injected with nicotine 40 μg/kg. Group C:were injected with melatonin, 10 μg/ night. Group D:were injecte...

introduction: drugs of abuse such as nicotine and morphine used systemically by addicts produce their effects via the mesolimbic dopaminergic pathway. furthermore, evidence indicates that some behavioral effects of nicotine and morphine are mediated by nitric oxide (no). based on these observations, the aim of the present study was to investigate the effects of intra-nucleus accumbens (nac) inj...

background: nicotine can pass through placental blood barrier and accumulate in the developing organs of fetus. also, entering the breast milk, nicotine can have an effect on the neonates. investigations have showed that collagen iv is one of the most important micro vessels basement membrane components. objective:  in this study, the effect of maternal nicotine exposure in pre and postnatal pe...

Tobacco smoking is one of the most serious health problems. Potentially lethal effects nicotine for adults can occur with as little 30 to 60 mg, although severe symptoms arise lower doses. Furthermore, route administration also influences toxicity. Cytisine popular medications in nicotinism treatment. Like nicotine, cytisine a plant alkaloid, signaling through nicotinic acetylcholine receptors....

Previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. Opiate and cigarette have been used concomitantly as drug abuse. The aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. All experiments wer...

Background and Objective: Infertility is a health problem that affects 72.4 million couples worldwide. Infertility can occur due to an unhealthy lifestyle, such as a smoking habit. A cigarette contains nicotine, a toxic compound that can trigger oxidative stress and eventually decrease fertility. Temulawak is a medicinal plant that is rich in antioxidants and anti-inflammatory properties. It ha...