Haemolysates of red blood cells from embryos of several developmental stages ranging from 2 to 21 incubation days and from post-hatching chickens of various age groups were analysed by ion-exchange chromatography, agarand starch-gel electrophoresis, immunoelectrophoresis with specific antisera and polypeptide chain electrophoresis. With these methods two adult (Ax and A2) and six embryonic (Ej-...

During 1978-81 there were about 43,500 births in Birmingham, of which 10.3% were to Negroes and 22.6% to Asians. Cellulose acetate electrophoresis of red cell haemolysates from capillary specimens collected for phenylketonuria screening was performed for these babies to assess the feasibility, cost, and benefits of detecting sickle haemoglobinopathies early. Eight babies had important haemoglob...

Haemoglobin E beta-thalassaemia is the commonest form of severe thalassaemia in many Asian countries, but little is known about its natural history, the reasons for its clinical diversity, or its optimal management. Despite its frequency, haemoglobin E beta-thalassaemia is often managed in an ill-defined and haphazard way, usually by demand transfusion. We studied a cohort of Sri Lankan patient...

AIMS To study the prevalence and long-term prognostic significance of changes in haemoglobin levels during hospital course in survivors of acute myocardial infarction (AMI). METHODS AND RESULTS A prospective study involving 1390 patients who were admitted with AMI. Median follow-up was 24 months. Multivariable Cox models were used to evaluate the relationship between nadir and discharge haemo...

BACKGROUND Limited epidemiological evidence suggests that low maternal iron status and anaemia in pregnancy may increase the risk of childhood respiratory and allergic outcomes. OBJECTIVES To investigate the relation between maternal haemoglobin concentrations in pregnancy and childhood respiratory and allergic outcomes. METHODS In the Avon Longitudinal Study of Parents and Children (ALSPAC...

When investigating a newly discovered haemoglobin L, using Itano's solubility test (Itano, 1953), a resemblance to sickle cell haemoglobin was noticed inasmuch as solubility was not complete in 2.24 M phosphate buffer. This was later realized to be due to an artefact (see Ager and Lehmann, 1957), but at that time the cells containing haemoglobin L were tested for sickling by incubation with red...

No one seems to have attempted to measure the reserve of iron available for haemoglobin synthesis in man. Hahn (1937) estimated that 57 per cent of the total iron in a dog was contained in the blood haemoglobin, 20 per cent was stored in a form potentially available for haemoglobin syn'thesis, and 23 per cent was bound in myohaemoglobin, cell enzymes, etc., and was not available for haemoglobin...

BACKGROUND Regional differences in haemoglobin values and process care measures were examined using data from the Centers for Medicare & Medicaid Services' End-Stage Renal Disease (ESRD) Clinical Performance Measures Project. It was posited that regional differences in haemoglobin values are consequent upon differences in components of clinical practice. METHODS A national random sample of 83...