Trends in Haematology contains review articles on selected topics by distinguished authors. The 25 subjects covered are wide-ranging and embrace clinical haematology, genetics, immunology and cytochemistry. Dr. Rosemary Briggs outlines the development of the present day theory of blood coagulation, Professor Herbert gives an excellent description of folic acid and vitamin B12 metabolism and Dr....

Down syndrome is a common congenital disorder affecting approximately 1/1000 live births. Newborns and children with Down syndrome may present with many haematological problems. In addition, benign abnormalities of the blood count and blood film, which may manifest at any age, population-based and cancer-based registries and clinical trials suggest there is a approximately 12-fold increased ris...