The aim of this study was to develop a method for the preparation of ferrous fumarate and folic acid oral dispersible tablets and their quality evaluation through HPLC and spectrophotometry. The formulation was optimized with dissolubility and dispersed uniformity as reference parameters by singlefactor and orthogonal experiments. The results exhibited that the optimal formulation contained: 18...

Objective: Methotrexate (MTX) is a folate antimetabolite used for the management of neoplastic diseases like leukemia and breast cancer, also in treatment psoriasis as well rheumatoid arthritis. The goal this research was to improving solubility dissolution profile methotrexate solid dispersion by using different polymers. Methods: A total six formulas were prepared solvent evaporation method p...

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 3(2) full factorial design. The ratio of HPMC K4M and PVP K30 (X(1)) and the concentration of melt binder (X(2)) were selected as independent variables, and drug release at 1 hr (Q(1)), 4 hr (Q(4)), 8 hr...

OBJECTIVE S Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease. MATERIALS AND METHODS Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitr...

A bacterial strain, isolated from a cyanobacterial culture, was identified as Pseudomonas sp. strain X40. Under iron-limiting conditions, the Pseudomonas sp. produced aerobactin, a dihydroxamate siderophore previously found only in the family Enterobacteriaceae. Aerobactin was identified by electrophoretic mobility, spectrophotometric titration, proton nuclear magnetic resonance spectroscopy, m...

The chromatin-associated enzyme PARP1 has previously been suggested to ADP-ribosylate histones, but the specific ADP-ribose acceptor sites have remained enigmatic. Here, we show that PARP1 covalently ADP-ribosylates the amino-terminal histone tails of all core histones. Using biochemical tools and novel electron transfer dissociation mass spectrometric protocols, we identify for the first time ...

The contribution provides a valorization alternative for rejected plastic wastes from mechanical-biological treatment (non-recyclable material) via an in-situ catalytic pyrolysis process focused on the production of liquid fraction with similar properties to traditional fuels (i.e., gasoline, kerosine, and diesel). According ASTM recommendations, small samples without prior physical separation,...