Mycobacterium marinum causes sporadic skin infection. It mostly appears on extremities with erythematous or bluish papule nodule at the inoculation site, usually after abrasions are exposed to contaminated water fish. A 43-year-old male patient no prior medical history noticed appearance of red lesions back his left shoulder 2 years earlier. Various physicians visited and misdiagnosed as contac...

The kinetics of inactivation of mycobacteria by ultraviolet light were investigated. Mycobacterium tuberculosis and M. marinum were shown to be capable of photo-reactivation.

The ESX-5 secretion system of Mycobacterium tuberculosis is important for bacterial virulence and for the secretion of the large PE/PPE protein family, whose genes constitute 10% of the M. tuberculosis genome. A four-gene region of the ESX-5 system is duplicated three times in the M. tuberculosis genome, but the functions of these duplicates are unknown. Here we investigated one of these duplic...

Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic pathological features of TBM are Rich foci, i.e. brain- and spinal-cord-specific granulomas formed after hematogenous spread of pulmonary tuberculosis. Little is known about the early pathogenesis of TBM and the role of Rich foci. We have adap...

Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic structures of NATs from M. smegmatis and M. marinum, as native enzymes and with isoniazid bound shar...

this study concerns the taxonomic status of hordeum marinum sensu lato in iran. itsgeographical distribution in iran has been reported. based on the morphological study, the taxoncontains two subspecies: marinum and gussoneanum (parl.) thell. in iran. morphological descriptionsalong with a key separating the two subspecies are provided. furthermore, morphological variations ofthe subspecies of ...

During a tuberculosis infection and inside lipid-laden foamy macrophages, fatty acids (FAs) and sterols are the major energy and carbon source for Mycobacterium tuberculosis. Mycobacteria can be found both inside a vacuole and the cytosol, but how this impacts their access to lipids is not well appreciated. Lipid droplets (LDs) store FAs in form of triacylglycerols (TAGs) and are energy reservo...

We demonstrated previously that susceptibility testing of Mycobacterium tuberculosis could be accomplished within 24 h after the organisms were incubated with antituberculosis agents by using fluorescein diacetate (FDA) staining and flow cytometry. Continued studies have now shown that assay suspensions containing M. avium, M. fortuitum, M. gordonae, or M. marinum incubated with various concent...