The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is composed of thousands of neuronal oscillators expressing different intrinsic periods. These oscillators form a coupled network with a free-running period around 24 h in constant darkness and entrainable to the external light-dark cycle (T cycle). Coupling plays an important role in setting the period of the networ...

We perform a systematic study in the computational complexity of the connected variant of three related transversal problems: Vertex Cover, Feedback Vertex Set, and Odd Cycle Transversal. Just like their original counterparts, these variants are NP-complete for general graphs. A graph G is H-free for some graph H if G contains no induced subgraph isomorphic to H . It is known that Connected Ver...

The complex seasonal, dust, and atmospheric circulation patterns at Mars affect the abundance spatial extent of water its photo-dissociated atomic byproduct H. Recent observations by Atmosphere Volatile Evolution (MAVEN) mission have been used to constrain H exobase (200 km altitude) as well thermal global escape rate. MAVEN span last seven years encompass effects declining phase Solar Cycle 24...

Utilizing centrifugal elutriation, early and late S-phase cells were separated from 4, 8 and 12 h anaerobically cultured Ehrlich Ascites tumor cells strain Karzel. The cytokinetic properties of these fractions after reaeration were studied by flow cytometry and the BrdU-H 33258-technique of flow cytometry. After a 4 h period of anaerobiosis, growth of early S-phase cells is not changed, 8 h dep...

Melanoma is a malignant tumor with high invasive and metastatic properties. Though radiation is the major therapy for melanoma, its radio-resistance has been shown to severely influence the clinical outcome. So it is imperative to enhance the sensitivity of uveal melanoma cells to radiotherapy. Previously, we found that the cell cycle of 92-1 uveal melanoma cells was suspended and remained unch...

Let T be a hamiltonian bipartite tournament with n vertices, γ a hamiltonian directed cycle of T , and k an even number. In this paper the following question is studied: What is the maximum intersection with γ of a directed cycle of length k contained in T [V (γ)]? It is proved that for an even k in the range n+6 2 ≤ k ≤ n−2, there exists a directed cycle Ch(k) of length h(k), h(k) ∈ {k, k − 2}...

Let T be a hamiltonian bipartite tournament with n vertices, γ a hamiltonian directed cycle of T , and k an even number. In this paper, the following question is studied: What is the maximum intersection with γ of a directed cycle of length k? It is proved that for an even k in the range 4 ≤ k ≤ n+4 2 , there exists a directed cycle Ch(k) of length h(k), h(k) ∈ {k, k−2} with |A(Ch(k))∩A(γ)| ≥ h...

background: breast cancer is the most common diagnosed cancer among women in the world. snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. traces of snail1 in metastasis of breast cancer to bone are observed. the aim of this study was to investigate the effect of specific snail1 sirnas on the prol...

We investigate minimum vertex degree conditions for 3-uniform hypergraphs which ensure the existence of loose Hamilton cycles. A loose Hamilton cycle is a spanning cycle in which consecutive edges intersect in a single vertex. We prove that every 3-uniform n-vertex (n even) hypergraph H with minimum vertex degree δ1(H) ≥ ( 7 16 + o(1) ) (n 2 ) contains a loose Hamilton cycle. This bound is asym...