نتایج جستجو برای: gyra gene

تعداد نتایج: 1142131  

Journal: :Antimicrobial agents and chemotherapy 2005
Beilei Ge Patrick F McDermott David G White Jianghong Meng

Point mutations in the topoisomerase (DNA gyrase A) gene are known to be associated with fluoroquinolone resistance in Campylobacter. Recent studies have shown that an efflux pump encoded by cmeABC is also involved in decreased susceptibilities to fluoroquinolones, as well as other antimicrobials. Genome analysis suggests that Campylobacter jejuni contains at least nine other putative efflux pu...

Journal: :The Journal of antimicrobial chemotherapy 2012
Tatsuya Akiyama Ashraf A Khan

OBJECTIVES To determine the fluoroquinolone resistance determinants in Salmonella enterica serovar Schwarzengrund from imported foods. METHODS Antibiotic susceptibility of Salmonella Schwarzengrund to 16 antibiotics was examined using disc agar diffusion and Etest. Quinolone resistance determinants were examined by sequence analysis of gyrA, gyrB, parC and parE, PCR amplification of qnrA, qnr...

Journal: :Antimicrobial agents and chemotherapy 2014
Zhijian Zhang Jie Lu Yufeng Wang Yu Pang Yanlin Zhao

China is one of the countries with the highest burdens of multidrug-resistant (MDR) and fluoroquinolone (FQ)-resistant tuberculosis (TB) globally. Nevertheless, knowledge about the prevalence and molecular characterization of FQ-resistant Mycobacterium tuberculosis isolates from this region remains scant. In this study, 138 M. tuberculosis isolates determined by the agar proportion susceptibili...

2011
Zhenling Cui Jie Wang Junmei Lu Xiaochen Huang Zhongyi Hu

BACKGROUND This study aimed to analyze the association of mutation patterns in gyrA and gyrB genes and the ofloxacin resistance levels in clinical Mycobacterium tuberculosis isolates sampled in 2009 from East China. METHODS The quinolone resistance-determining region of gyrA/B were sequenced in 192 M. tuberculosis clinical isolates and the minimal inhibitory concentrations (MICs) of 95 ofloxa...

Journal: :Journal of infection in developing countries 2012
Rula Al-Dawodi Mohammad A Farraj Tamer Essawi

INTRODUCTION The efficacy of chemotherapy can be compromised by drug resistance. This study was undertaken to describe the resistance profiles and fluoroquinolone resistance mechanism of non-typhoidal Salmonella (NTS) isolated from humans and poultry in West Bank, Palestine. METHODOLOGY One hundred and fifty-one isolates of NTS, obtained from humans (71) and poultry (80), collected between Se...

Journal: :The Journal of antimicrobial chemotherapy 2003
Daniel Jonas Inge Engels Doris Hartung Jan Beyersmann Uwe Frank Franz D Daschner

The potential for selection in vitro of Legionella pneumophila mutants resistant to fluoroquinolones was investigated. Six distinct clinical isolates of L. pneumophila were subcultured in subinhibitory concentrations of ciprofloxacin, levofloxacin, clinafloxacin, trovafloxacin and moxifloxacin until MICs increased at least eight-fold. The numbers of serial passages required in microbroth diluti...

Journal: :International microbiology : the official journal of the Spanish Society for Microbiology 2010
Antonina Arias Cristina Seral M José Gude F Javier Castillo

Mutations in quinolone targets were studied together with quinolone efflux pump activation and plasmid-mediated quinolone resistance determinants in nalidixic-acid-resistant isolates of Aeromonas caviae and Aeromonas veronii. Among 135 clinical Aeromonas spp. isolated from stools of patients with gastrointestinal symptoms, 40 nalidixic acid-resistant strains belonging to A. caviae and A. veroni...

2011
Marzieh Aligholi Akbar Mirsalehian Shahnaz Halimi Hossein Imaneini Morovat Taherikalani Fereshteh Jabalameli Parisa Asadollahi Babak Mohajer Alireza Abdollahi Mohammad Emaneini

BACKGROUND Fluoroquinolones are broad-spectrum antibiotics widely used in the treatment of bacterial infections such as Staphylococcus aureus isolates. Resistance to these antibiotics is increasing. MATERIAL/METHODS The occurrence of mutations in the grlA and gyrA loci were evaluated in 69 fluoroquinolone-resistant S. aureus isolates from 2 teaching hospitals of Tehran University of Medical S...

Journal: :Journal of medical microbiology 2004
Shigeru Fujimura Seiichi Kato Kazuie Iinuma Akira Watanabe

Resistance to antibiotics, especially clarithromycin, is the major cause of the failure to eradicate Helicobacter pylori. There are few studies in children concerning fluoroquinolone activity against H. pylori. Primary resistance to antibiotics including fluoroquinolones was studied in 55 H. pylori strains isolated from Japanese children. DNA sequences of the gyrA gene in fluoroquinolone-resist...

Journal: :The new microbiologica 2016
Izabela Korona-Glowniak Kinga Skrzypek Radosław Siwiec Andrzej Wrobel Anna Malm

Fluorochinolones are a class of broad-spectrum antimicrobials in the treatment of several infections, including those caused by Escherichia coli. Due to the increasing resistance of bacteria to antimicrobials, an understanding of fluoroquinolone resistance is important for infection control. The aim of this study was to determine susceptibility of clinical E. coli strains to fluoroquinolones an...

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