This study aimed to investigate LDL subfraction distribution as well as serum cholesteryl ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), and paraoxonase (PON1) activity in streptozotocin-induced diabetic guinea pigs. Materials/Methods. Guinea pigs were given a single intraperitoneal (ip) injection of streptozotocin (STZ) and animals having fasting blood glucose leve...

The decoction of Pheretima aspergillum is used as a traditional medicine for treatment of asthma in China with a long clinical history. The aim of the study was to investigate the anti-asthma activities of an active components group obtained from the decoction of Pheretima aspergillum in histamine and ovalubumin induced asthma guinea pigs. The incubation period of asthma, serum IFN-γ, IL-4 and ...

An invisible, filter-passing virus, pathogenic for the guinea pig, and capable of cultivation on special media for at least seven generations, has been isolated from a tick of the species Dermacentor andersoni. One of two monkeys (Macacus rhesus) inoculated became infected, and in one rabbit the result was negative. The virus has been transmitted from infected guinea pigs to ticks as also in on...

the purpose of this study was to determine the therapeutic efficacy of citric and tartaric acids on experimental dermatophytosis in guinea pigs. in this study, the susceptibility of trichophyton mentagrophytes var. mentagrophytes to citric and tartaric acids was assessed using the macrodilution broth method. in the animal experiments, a cream consisting of the mixed acids was topically applied ...

background: postoperative peritoneal adhesion bands are one of the most common complications caused by foreign material.   objective: to investigate the effect of colchicine on talc-induced peritoneal adhesion bands.   method: adhesion bands were induced in 30 short hair england guinea pigs by introduction of talc-saline solution (10 ml, 10%) into the peritoneal cavity.  afterwards, the pigs we...

HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29) has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (HSV529) derived from dl5-29 have not been evaluated. Humo...

asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. onosma bracteatum ( o. bracteatum ) is known tradit...

Germ-free guinea pigs died with signs and lesions of acute enterotoxemia after oral ingestion of C. perfringens types B, C, D, and E. The signs and lesions observed resembled those seen in acute enterotoxemia of sheep and cattle and the naturally occurring disease seen in "ex-germ-free" guinea pigs. C. perfringens type A was found to be innocuous. Conventional guinea pigs did not become ill aft...

The influence of oxidized frying oil (OFO) on the guinea pig hepatic microsomal xenobiotic-metabolizing enzyme system in the presence of different amounts dietary vitamin C was investigated. Weanling male guinea pigs were divided into four groups and were fed 15% oxidized frying oil diets supplemented with vitamin C at 300, 600, or 1,500 mg/kg (experimental diets) or a control diet that contain...