CD4 + T cells are critical for host defense but are also major drivers of immune-mediated diseases. The classical view of Th1 and Th2 subtypes of CD4 + T cells was recently revised by the identification of the Th17 lineage of CD4 + T cells that produce IL-17, which have been found to be critical in the pathogenesis of autoimmune and other diseases. Mechanisms controlling the differentiation of ...

TNF-a is a cytokine with antitumorigenic property. In contrast, low dose, chronic TNF-a production by tumor cells or stromal cells may promote tumor growth andmetastasis. Serum levels of TNF-a are significantly elevated in renal cell carcinoma (RCC) patients. Here, we showed that TNF-a induced epithelial–mesenchymal transition (EMT) and promoted tumorigenicity of RCC by repressing E-cadherin, u...

Abstract Popular culture and medical lore have long postulated a connection between full moon exacerbations of psychiatric disorders. We wanted to empirically analyze the hypothesis that suicides are increased during period around moons. analyzed pre-COVID from Marion County Coroner’s Office (n = 776), show deaths by suicide significantly week (p 0.037), with older individuals (age ≥ 55) showin...

The study aimed to determine the effect of feeding dietary ulvan on some genes and pathways Penaeus vannamei juveniles. Feeding a diet containing at 1.0 g·kg-1 resulted in differentially expressed (DEGs) between treatments control group. Ulvan 53 DEGs with 26 up 27-down-regulated DEGs. were immune-related, while several affected energy substrate metabolic pathways. Specific upregulated Glycerol...

Tobacco smoking has been correlated with a lower incidence of Alzheimer's disease (AD). This negative correlation has been attributed to nicotine's properties. However, the undesired side-effects of nicotine and the absence of clear evidence of positive effects of this drug on the cognitive abilities of AD patients have decreased the enthusiasm for its therapeutic use. In this review, we discus...

The reliability of reverse transcription-quantitative PCR (RT-qPCR) results in gene expression studies depends on the approaches used to account for non-biological variations. In order to find a proper normalization strategy for the study of genes related to growth hormone signaling in skeletal muscle of growing mice, nine unrelated genes were evaluated as internal controls. According to the mo...