This paper describes many of the challenges encountered when establishing a large multicentre trial in cardiac anesthesia. We address funding, authorship, multisite ethics review, patient recruitment, data quality management, communication with individual sites, and strategies to enhance cooperation and patient recruitment.

Critical appraisal is an element of evidence-based medicine, which is defined as the process of carefully and systematically examining a research article to determine its reliability, validity and value in clinical practice. The major components evaluated in critical appraisal are validity, importancy, and applicability. The level of reliability of study results depend on the design of study, i...

prebiotic: a nondigestible food ingredient that benefits the host by selectively stimulating the favorable growth and/ or activity of 1 or more indigenous prebiotic bacteria. prebiotics can modify the intestinal flora and interact with the immune system of the host against specific pathogens. however clinical trials are currently limited and a beneficial effect of prebiotic in treatment acute d...

BACKGROUND Treatment guidelines for asthma recommend inhaled corticosteroids (ICS) as first-line therapy for children with persistent asthma. Although ICS treatment is generally considered safe in children, the potential systemic adverse effects related to regular use of these drugs have been and continue to be a matter of concern, especially the effects on linear growth. OBJECTIVES To assess...

A series of field trials have been established as part of the ACIAR Smallholder Tree Farmer Project. These trials are designed to have both a research and demonstration function. A field trial was designed to investigate the potential interaction between four species providing a combination of native and exotic species and nitrogen-fixing vs non-nitrogen-fixing. Importantly, this design provide...

Although there is increasing evidence that vitamins influence pancreatic adenocarcinoma biology and carcinogenesis, a comprehensive review is lacking. In this study, we performed a PubMed literature search to review the anticancer mechanisms and the preclinical and clinical studies that support the development of the bioactive vitamins A, C, D, E, and K in pancreatic cancer intervention. Precli...

Angiogenic therapy, which involves the use of an exogenous stimulus to promote blood vessel growth, is an attractive approach for the treatment of ischemic diseases. It has been shown in animal models that the stimulation of blood vessel growth leads to the growth of the whole vascular tree, improvement of ischemic tissue perfusion and improved muscle aerobic energy metabolism. However, very fe...

Prebiotic: A nondigestible food ingredient that benefits the host by selectively stimulating the favorable growth and/ or activity of 1 or more indigenous prebiotic bacteria. Prebiotics can modify the intestinal flora and interact with the immune system of the host against specific pathogens. However clinical trials are currently limited and a beneficial effect of prebiotic in treatment acute d...

OBJECTIVE To evaluate effect of various regimens for administration of antimicrobials in feed on growth rate and feed efficiency (feed/gain) of pigs in multisite production systems. DESIGN Controlled trial. ANIMALS 24,099 growing pigs in 3 multisite production systems. PROCEDURE 10 trials involving various regimens for administration of antimicrobials in feed were evaluated. Trial 1 compa...