Two contrasting cases of amiodarone hepatotoxicity are described. In one, perivenular collections of swollen cells, probably macrophages, with granular cytoplasm in an otherwise nearly normal liver were observed. Transmission electron microscopy showed that the cytoplasmic granularity was due to lysosomal bodies of various sizes. X-ray energy and wavelength spectroscopic analysis showed a high ...

Previous studies evidenced that cystatin B-like gene is specifically expressed and induced in large circulating coelomic cells following bacterial challenge in the leech Theromyzon tessulatum. In order to understand the role of that cysteine proteinase inhibitor during immune response, we investigated the existence of members of cathepsin family. We cloned a cathepsin L-like gene and studied it...

The mormyrid electric …sh displays extremely …ne temporal resolution as measured in behavioral studies. The …rst stage of sensory processing, the sensory a¤erents, also display very precise temporal responses to electrical stimulation. The a¤erents are connected through gap junctions to the granular cells, which in addition receive a corollary discharge signal at the time of the electric pulse....

The intestinal epithelium is a heterogeneous cell monolayer that undergoes continuous renewal and differentiation along the crypt-villus axis. We have used transgenic mice to examine the compartmentalization of a regulated endocrine secretory protein, human growth hormone (hGH), in the four exocrine cells of the mouse intestinal epithelium (Paneth cells, intermediate cells, typical goblet cells...

Granular cell tumour is a rare soft tissue neoplasm that can virtually affect any site of the body. Its histological origin is controversial, since several studies have shown that different cells are involved. Granular cell tumour was initially described as myoblastoma, but, at present, a neural origin is supported by most Authors, due to the immunohistochemical pattern. Even if the biological ...

An examination of the mucosal epithelium of the urinary bladder of the toad reveals that the two major cell types which abut on the urinary surface, the granular and mitochondria-rich cells, also contact the basement membrane. Thus, the epithelium functions as a single cell layer. Although basal cells are interpolated between the granular cells and the basement membrane over a large portion of ...

The intestinal epithelium is a heterogeneous cell monolayer that undergoes continuous renewal and differentiation along the crypt-villus axis. We have used transgenic mice to examine the compartmentalization of a regulated endocrine secretory protein, human growth hormone (hGH), in the four exocrine cells of the mouse intestinal epithelium (Paneth cells, intermediate cells, typical goblet cells...

The ultrastructures of the pituitary pars intermedia of 11 male sheep about 1-13 months of age were observed. The following cells were distinguished in the sheep pars intermedia: pars intermedia glandular cells, marginal cells, interstitial cells, follicular cells, pars distalis-like granular cells, degenerating cells and mast cells. The pars intermedia glandular cells contain a well-developed ...

Ameloblastoma is a slow-growing and locally invasive epithelial odontogenic tumor of the jaw that runs benign course in most cases. Granular cell ameloblastoma rare subtype ameloblastoma, showing granular transformation its cytoplasm. It considered as an aggressive variant ameloblastoma. Herein, we report case 34-year-old male patient who presented with swelling left cheek for 1-year duration r...

In this study, we offer a general view at the area of fuzzy modeling and fuzzymodels, identify the visible development phases and elaborate on a new and promisingdirections of system modeling by introducing a concept of granular models. Granularmodels, especially granular fuzzy models constitute an important generalization of existingfuzzy models and, in contrast to the existing models, generat...