water soluble chitosan oligosaccharide (cho) was hydrophobically modified with camptothecin (cpt) in different molar ratios of cpt, and characterized by ft-ir and 1 h-nmr spectroscopy. nanomicelles prepared by these copolymers were analyzed for size, zeta, and length of time they remain stable. the critical micelle concentration (cmc) and dissociation of micelles at physiological ph and acidic ...

An improved adenoviral-based gene delivery vector was developed by complexing adenovirus (Ad) with a biocompatible, grafted copolymer PEG-g-PEI composed of polyethylene glycol (PEG) and polyethylenimine (PEI). Although an Ad-based gene vector is considered relatively safe, its native tropism, tendency to elicit an immune response, and susceptibility to inactivating antibodies makes the virus le...

Stabilization of nucleic acid assemblies, such as duplex and triplex, is quite important for their wide variety of potential applications. Various stabilization methods, including molecular designs of chemically modified nucleotides and hybrid stabilizers, and combinations of different stabilization methods have been developed to increase stability of nucleic acid assemblies. However, combinati...

Abstract Grafting of styrene (S) onto biopolymer Sodium Alginate (NaAlg) via free-radical polymerization forming (NaAlg-g-PS), using potassium persulfate K 2 S O 8 (KPS) as initiator. Fourier-transform infrared spectroscopy (FT-IR) and Proton nuclear magnetic resonance ( 1 H-NMR) characterized the formed grafted copolymer scanning electron microscope (SEM) to show changes in surface morphology ...