Cancer disease is the second leading cause of death in the world and one of the main fields of medical research. Although there is now a greater understanding of biological mechanisms of uncontrolled cell growth, invasiveness and metastasization, the multistep process of cancer development and evolution is still incompletely understood. The inhibition of molecules activated in cancer metastasiz...

Genetic and environmental factors are implicated in the timing of puberty (1). Human studies have shown a relationship between body mass index or body fat, dietary and physical activity with the timing of puberty (2, 3, 4). More recently a G-protein coupled receptor, GPR54 and its ligand Kisspeptin have been identified as important signals in pubertal induction (5). The role of leptin in the pu...

The paper analyzes the scientific data included the author's own results about the opportunities to increase the reproductive potential of female animals by application of the natural no hormonal substances and the supposed mechanisms of their action on the reproductive system. Also the new scientific data related to the discovering of the "metabolic" hormones (leptin, ghrelin) and kisspeptin/G...