In this paper, a fast and sensitive localized surface plasmon resonance (LSPR) based biosensor was developed and the optimization of gold – antibody conjugates through investigation of different parameters were performed. Gold nanoparticles (AuNPs) with a size of ~20 nm were synthesized via chemical reduction of HAuCl4 with trisodium citrate as reducing and stabilizing agent. The impacts of pH ...

Abstract Gold nanoparticles (AuNPs) are well-known biomedical and biotechnological applications because of their interesting properties. They easily cross the cell membranes interact with intracellular materials. This study was designed to investigate interaction calf spleen DNA AuNPs at a molar ratio 2:1 in an aqueous solution different ionic strengths (10, 50, 100%). AuNPs/DNA complex were ch...

Gold nanoparticles (AuNPs) can be used as delivery vehicles for platinum anticancer drugs, improving their targeting and uptake into cells. Here, we examine the appropriateness of different-sized AuNPs as components of platinum-based drug-delivery systems, investigating their controlled synthesis, reproducibility, consistency of drug loading, and stability. The active component of cisplatin was...

Plasmonics, is an emerging subfield of nanophontonics, and it attracts increasing attention because of its potential applications in controlling and manipulating light at nanoscale dimensions. The advent of dark-field microscopy (DFM) has enabled the study of plasmonic nanoparticles, especially the coinage metals and the effects of their size, shape, composition as well as the local environment...

In this Letter, dynamic wetting of water nano-droplets containing non-surfactant gold nanoparticles on a gold substrate is examined via molecular dynamics simulations. The results show that the addition of non-surfactant nanoparticles hinders the nano-second droplet wetting process, attributed to the increases in both surface tension of the nanofluid and friction between nanofluid and substrate...

The optical and morphological properties of lustrous metal self-healing liquid-like nanofilms were systematically studied for different applications (e.g., optical mirrors or filters). These nanofilms were formed by a one-step self-assembly methodology of gold nanoparticles (AuNPs) at immiscible water-oil interfaces, previously reported by our group. We investigated a host of experimental varia...

This work reportson plasmonic effects (i.e light scattering and absorption properties) induced by two different gold nanoparticles (AuNPs)-shaped: spherical particle triangular particle. The cross-section electric field profiles have been investigated using theboundary element method (MNPBEM toolbox). Two configurations: the isolated AuNPand coupledtwo-gold NPsystem considered to evaluate local...

A new signal amplification strategy based on simultaneous application of gold nanoparticles (AuNPs) and horseradish peroxidase (HRP) was employed to improve the sensitivity of an electrochemical immunoassay for detection of human IgG (hIgG), as a model antigenic protein. This immunoassay system was fabricated on magnetic carboxyl-functionalized multi-walled carbon nanotubes (COOH-MWCNT/Fe3...

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lyi...

An imine-based approach was developed to prepare Janus gold nanoparticles (Janus AuNPs) having amine functionality on one patch of the surface and a polyethylene glycol unit on the other. This unique technique features covalent bonding as the force to immobilize AuNPs on the template, enabling direct modification of AuNPs in both water and organic solvents. Colloidal clusters were then obtained...