The objective of the present investigation was to study antidiabetic activity of standardized extract of Trigonella foenum-graecum seeds (IND01) using neonatal streptozotocin-induced rat (n-STZ) model of diabetes mellitus (DM) in rats for the first time. Streptozotocin (STZ) was injected (50 mg/kg i.p.) in pups of rats in a split dose manner (on 2nd and 3rd postnatal days). After 8 weeks, DM wa...

BACKGROUND Coadministration of co-trimoxazole with sulfonylureas is reported to increase the risk of hypoglycemia. METHODS We identified a cohort of Medicare beneficiaries aged 66 years or older who took glyburide or glipizide for diabetes from a 5% national sample of Medicare Part D claims data in 2008 (n = 34,239). We tracked each participant's claims during 2008-2010 for a co-trimoxazole p...

A term male infant was born by spontaneous vaginal delivery to a 23 year old gravida 2 para mother. His weight, length, and head circumference were 2720g (8%), 47cm (6%) 31.5cm (1%) respectively; the remainder of his physical examination unremarkable. The pregnancy complicated intra-uterine growth retardation, gestational diabetes controlled with glyburide, thrombocytopenia. mother had past med...