The basis of resistance to oxidative injury was studied in six murine tumor cell lines that differed 54-fold in their resistance to enzymatically generated H(2)0(2). The tumors varied 56.7-fold in their specific activity of catalase, 5.3-fold in glutathione peroxidase (GPO), 3.3-fold in glutathione reductase (GR), and 2.7-fold in glutathione. There was no correlation among the levels of the thr...

The response of enzymatic (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPX and glutathione reductase, GR) and non-enzymatic responses (glutathione, GSH, oxidized glutathione, GSSG and GSH/GSSG) against acute Cu toxicity (2-90μg/mL for 48h) in different tissues of Lymnaea stagnalis were measured. Incubation conditions for enzymatic activity measurements were optimized for L...

Erectile dysfunction (ED) drugs have been used for treatment of erectile dysfunction which affects the lives of approximately 300 million men worldwide. It is well known that the cytosolic glutathione Stransferase (GST) and glutathione metabolizing enzymes play an important role in the detoxification of many endogenous and exogenous compounds. Therefore, the present study aims at investigating ...

OBJECTIVE to compare the activities of antioxidative enzymes in erythrocytes between centenarians and a younger group of elderly subjects. DESIGN cross-sectional study. SETTING county of Funen, Denmark. SUBJECTS 41 centenarians aged between 100 and 105 years and 52 community control subjects aged between 60 and 79 years. MEASUREMENTS enzyme activities of superoxide dismutase (CuZn-SOD),...

Plasmodium falciparum (Pf) like most other organisms, has a sophisticated antioxidant system, part of which includes glutathione reductase (GR). GR works by recycling toxic glutathione disulfide to glutathione, thereby reducing reactive oxygen species and making a form of glutathione (GSH) the parasite can use. Inhibition of this enzyme in Pf impedes parasite growth. In addition, it has been co...

Oxidative stress is implicated in the pathogenesis and/or complications of hypertension and/or diabetes mellitus. A combination of these disorders increases the risk of developing cardiovascular events. This study investigated the effects of streptozotocin (60 mg/kg; ip)-induced diabetes on blood pressure, oxidative stress and effects of honey on these parameters in the kidneys of streptozotoci...

In diabetic patients, persistence of hyperglycemia has been reported as a cause of increased production of oxygen free radicals. Hyperglycemia could induce oxidative stress and become the main factor for predisposing the complications in diabetes. The study is being aimed to find out the status of lipid peroxidation product i.e. malondialdehyde (MDA) and antioxidant enzymes (AOEs) such as gluta...

background: hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. the hepatoprotective effect of satureja khuzestanica essential oil (skeo), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated. methods: adult male sprague dawley rats were divided i...

Chilling whole rice seedlings at 5 degrees C significantly increased the time needed to recover linear growth and reduced the subsequent linear rate of radicle growth. Subjecting nonchilled seedlings to a 45 degrees C heat shock for up to 20 min did not alter subsequent growth, whereas a 3 min heat shock was optimal in reducing growth inhibition caused by 2 days of chilling. The activity of fiv...

Bangia fuscopurpurea is a widespread intertidal seaweed that commercially cultured in China. This frequently exposed to hyposalinity stress, but little known about the adaptation mechanisms. Ascorbate−glutathione (AsA−GSH) cycle plays important roles many organisms under variety of abiotic including hyposaline stress. In this study, we investigated response key metabolites and enzymes involved ...