Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake...

Glutaric aciduria type 1 (GA1), resulting from the genetic deficiency of glutaryl-CoA dehydrogenase (GDH), is a relatively common cause of acute metabolic brain damage in infants. Encephalopathic crises may be prevented by carnitine supplementation and diet, but diagnosis can be difficult as some patients do not show the typical excretion of large amounts of glutaric and 3-hydroxyglutaric acids...

organic academia are diverse group of disorders characterized by abnormal degredation of specific amino acid in the specific catabolism due to an enzymeactivity defect which mainly due to enzyme deficiency. the majority of the classic organic acid disorders are caused by abnormal catabolism of branched-chain amino acids like lysine. maple syrup urine disease (msud), propionic acidemia, methylma...

Abstract Two new Zn( ii ) coordination complexes [Zn(L)(dna)(H 2 O)] ( 1 and [Zn(L)(glu)] ·H O (L = 2-(4-fluorophenyl)-1 H -imidazo[4,5- f ][1,10]phenanthroline, dna 3,5-dinitrosalicylic acid, glu glutaric acid) have been hydrothermally synthesized characterized by single crystal X-ray diffraction, elemental analysis, fluorescence spectrum, infrared spectroscopy. For complex , the 2− anion adop...