The delivery of oxygen to the cell depends in good measure upon the affinity with which hemoglobin binds oxygen or releases it from erythrocytes for use by the other cells of the body. The release of oxygen by normal human hemoglobin A, over a range of partial pressures of oxygen, may be represented graphically by the familiar, sigmoid-shaped, oxygen dis-sociation curve. Numerically, the affini...

Hydroxyurea is a newly approved therapeutic agent for the treatment of sickle-cell disease. Hydroxyurea reduces the number of painful crises in sicklecell patients presumably by increasing the levels of fetal hemoglobin, which has a large solubilizing effect on sickle-cell hemoglobin and reduces polymerization (1). Despite being used to treat a number of cancers for nearly 30 years, the mechani...

BACKGROUND Anaemia is associated with adverse outcomes including early death in the first year of antiretroviral therapy (ART). This study reports on the factors associated with persistent anaemia among HIV-infected patients initiating ART in the Democratic Republic of Congo (DR Congo). METHODS We conducted a retrospective cohort study and analyzed data from patients receiving HIV care betwee...

We measured total hemoglobin (CtHb) and carboxyhemoglobin (COHb) in 100 patients' blood samples by using five specialized spectrophotometers (CO-oximeters)--IL 482 CO-Oximeter, Corning 2500 CO-oximeter, Radiometer OSM 3 Hemoximeter, Corning 270 CO-oximeter, and the AVL 912 CO-Oxylite--and compared the results with those obtained with the manual cyanmethemoglobin method and a gas-chromatographic...

BACKGROUND Co-trimoxazole prophylaxis can reduce mortality from untreated HIV infection in Africa; whether benefits occur alongside combination antiretroviral therapy (ART) is unclear. We estimated the effect of prophylaxis after ART initiation in adults. METHODS Participants in our observational analysis were from the DART randomised trial of management strategies in HIV-infected, symptomati...

OBJECTIVE To diagnose iron deficiency anemia in children. METHODS The study was conducted with a sample of 301 children aged six to 30 months attending public daycare centers in the city of Recife, Northeast Brazil, in 2004. The diagnoses of anemia were based on a combination of different hematological and biochemical parameters: hemoglobin, mean corpuscular volume, ferritin, C-reactive prote...

<p><span>Undernutrition is a type of malnutrition. Malnutrition can endanger human life, particularly that children. Honey, which has high nutritional value, one the components be utilized to alleviate Zinc tablets, in addition honey, are thought boost hemoglobin (Hb) and albumin levels. Zinc, as an antioxidant catalyst for biochemical events, aids organ healing, by restoring role e...

Near-infrared (NIR) Raman spectroscopy was used to measure spectra of dried human blood samples from multiple donors. Two major questions addressed in this paper involve the influence of sample heterogeneity and potential Raman spectral variations that could arise between different donors of blood. Advanced statistical analysis of spectra obtained from multiple spots on dry samples showed that ...