H(2)S generated by the enzyme cystathionine-γ-lyase (CSE) has been implicated in O(2) sensing by the carotid body. The objectives of the present study were to determine whether glomus cells, the primary site of hypoxic sensing in the carotid body, generate H(2)S in an O(2)-sensitive manner and whether endogenous H(2)S is required for O(2) sensing by glomus cells. Experiments were performed on g...

Onychomatricoma and glomus tumor are two rare subungual neoplasms with distinct clinical and histopathological features. We report a case of onychomatricoma associated with a glomus tumor in the subungual region of the same finger in a 45-year-old woman. Histopathological examination revealed characteristic findings of both onychomatricoma and glomus tumor. To the best of our knowledge, these t...

Glomus tumor is a rare, benign neoplasm rising from the glomus apparatus of the skin. It occurs most frequently on fingers and toes and accounts for 1.6% of all soft tissue tumors. Clinical diagnosis may prove difficult if the tumor occurs on an extra digital location. We report a case of a vascular-type glomus tumor (glomangioma) found in an atypical location, namely the lateral aspect of the ...

In our quest for novel genes required for the development of the embryonic peripheral nervous system (PNS), we have performed three genetic screens using MAb 22C10 as a marker of terminally differentiated neurons. A total of 66 essential genes required for normal PNS development were identified, including 49 novel genes. To obtain information about the molecular nature of these genes, we decide...

Patient's question " Doctor, please wait before rushing off. I have a question for you. Do I have cancer? Please be direct and honest with me, and explain to me the truth about what you know about cancer in a manner that I, as a layman, will be able to understand what you tell me. Most importantly, what is cancer, and what causes cancer? If I have cancer, how long will I live, and will I have j...

Aglomus tumour of the finger is a benign tumour that develops from the neuromyoarterial elements of the glomus body, which is a specialised arteriovenous anastomosis involved in thermoregulation. In this structure the arterioles that connect with venules have a thick layer of concentrically arranged epitheloid smooth muscle cells. Contraction of the layer of smooth muscle cells results in closu...