BACKGROUND Renal impairment is routinely assessed using the estimated glomerular filtration rate (eGFR) and it may be helpful to obtain certain clinical or laboratory markers, which show relationship with glomerular filtration rate (GFR) in sickle cell disease (SCD). AIM To assess the relationship between important clinical and laboratory parameters in SCD, and the eGFR. PATIENTS AND METHOD...

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Although several groups are working on developing and validating biomarkers of kidney injury and the glomerular filtration rate (GFR), the proposed diagnostic criteria from the Acute Kidney Injury Network are based on an absolute increase in serum creatinine ≥0.3 mg/dl (≥26.4 μmol/l), a percenta...

Microalbuminuria, an early feature of diabetic nephropathy, indicates intrarenal endothelial damage. In type 2 diabetes, microalbuminuria is strongly related to insulin resistance. We therefore investigated whether rosiglitazone, an insulin-sensitizing drug that is known to improve endothelial dysfunction, was able to improve intrarenal endothelial dysfunction and microalbuminuria. Nineteen typ...

Epidemiological studies have shown that obesity is associated with chronic kidney disease and end stage renal disease. These studies have used creatinine derived equations to estimate glomerular filtration rate (GFR) and have indexed GFR to body surface area (BSA). However, the use of equations using creatinine as a surrogate marker of glomerular filtration and the indexation of GFR for BSA can...

The application of serum creatinine and cystatin C in patients with CKD has been limited to using estimated glomerular filtration rate (eGFR). Criteria for choosing the best GFR estimating equation are 1) accuracy in estimating measured GFR, 2) optimal discrimination of clinical outcomes, and 3) association with CKD risk factors and outcomes similar to that of measured GFR. Notably, these crite...

The serious limitations of the estimating glomerular filtration rate (eGFR) appear related not to a shortcoming of the equation, but to the futility of trying to force agreement between two inherently different parameters: a blood marker of kidney function with a very stable concentration (creatinine) and a renal filtration parameter that fluctuates continually (glomerular filtration rate, GFR)...

conclusions functional renal impairment in diseases caused by hcv was more important than in diseases caused by hbv. the egfr was statistically lower in cirrhosis secondary to hcv than in hcv chronic hepatitis. results hbv chronic hepatitis, hcv chronic hepatitis, and cirrhosis secondary to these viruses were associated with a reduction of the gfr. the egfr was higher in patients with hbv chron...

conclusions our study shows a relationship between cimt and renal parameters, including egfr and albuminuria. this study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors. patients and methods this cross-sectional study was included 205 patients with type 2 diabetes mellitus (t2dm). we recorded clinical and biochemical data su...

background: in this study, the early effects of percutaneous nephrolithotomy (pcnl) on glomerular filtration rate (gfr) was assessed in different postoperative times and likewise, we determined the correlation of different variables with significant postoperative gfr drop  after pcnl. m aterials and methods: patient records of 486 cases that had undergone pcnl from january 2010 to october 2011 ...

BRAUN, ELDON J., AND WILLIAM H. DANTZLER. Effects of ADH on single-nephron glomerular Jiltration rates in the auian kidney. Am. J. Physiol. 226( 1) : 1-8. 1974.-Effects of ADH (arginine vasotocin) on the total-kidney glomerular filtration rate (GFR) and on single-nephron glomerular filtration rates (SNGFR) of reptilian-type (RT) and mammalian-type (MT) nephrons were studied in desert quail, Lop...