BACKGROUND Laryngeal hypersensitivity may be an important component of the common disorders of laryngeal motor dysfunction including chronic refractory cough, pdoxical vocal fold movement (vocal cord dysfunction), muscle tension dysphonia, and globus pharyngeus. Patients with these conditions frequently report sensory disturbances, and an emerging concept of the 'irritable larynx' suggests comm...

In this paper, we compare two implementations of a grid-based software system on the grid middleware Globus Toolkit 4 and gLite, respectively. This system called “Grid-Enabled SEE++” is a grid-based simulation software that supports the diagnosis and treatment of certain eye motility disorders (strabismus). First, we developed a parallel version of the software with the help of Globus 4. Since ...

In this paper, we compare two implementations of a grid-based software system on the grid middleware Globus Toolkit 4 and gLite, respectively. This system called “Grid-Enabled SEE++” is a grid-based simulation software that supports the diagnosis and treatment of certain eye motility disorders (strabismus). First, we developed a parallel version of the software with the help of Globus 4. Since ...

Deep brain stimulation (DBS) therapy has become an essential tool for treating a range of brain disorders. In the resting state, DBS is known to regularize spike activity in and downstream of the stimulated brain target, which in turn has been hypothesized to create informational lesions. Here, we specifically test this hypothesis using repetitive joint articulations in two non-human Primates w...

We have evaluated the feasibility of using four positron emission tomography (PET) tracers for imaging the globus pallidus by ex vivo autoradiography in rats. The tracers investigated were [11C]KF18446, [11C]SCH 23390 and [11C]raclopride for mapping adenosine A2A, dopamine D1 and dopamine D2 receptors, respectively, and [18F]FDG. The highest uptake by the globus pallidus was found for [11C]SCH ...

In this paper, we compare two implementations of a grid-based software system on the grid middleware Globus Toolkit 4 and gLite, respectively. This system called “Grid-Enabled SEE++” is a grid-based simulation software that supports the diagnosis and treatment of certain eye motility disorders (strabismus). First, we developed a parallel version of the software with the help of Globus 4. Since ...

The globus pallidus plays a critical role in movement regulation. Morphological study has indicated that the globus pallidus receives neurotensinergic innervation from the striatum. The present study investigated the effects of activating neurotensin receptor in globus pallidus. In vivo single unit electrophysiological recordings showed that micro-pressure ejection of neurotensin into the globu...

The Globus project is a multi-institutional research effort that seeks to enable the construction of computational grids providing pervasive, dependable, and consistent access to high-performance computational resources, despite geographical distribution of both resources and users. Computational grid technology is being viewed as a critical element of future highperformance computing environme...

We propose that research data management capabilities be delivered to users as hosted “software as a service” (SaaS). We report on a system, Globus Online, that adopts this approach, initially for a small set of data movement functions. Globus Online leverages modern Web 2.0 technologies to provide fire-and-forget file transfers, automatic fault recovery, and high performance, while also simpli...