Diabetes is a chronic metabolic disease and management of DM begins with helthy lifestyle early administration antidiabetic drug. Metformin the first line therapy in DM. Combination given if blood sugar level HbA1c cannot be controlled single therapy. This study aimed to determine effect giving metformin metformin+glimepiride on levels DM2 patients. The inclusion criteria were patients DM, rece...

Comparison effect of Pioglitazone and Glimepiride alone on renal function marker in experimentally induced damage diabetic rats.Jagdish Kakadiya, Nehal Shah

The ATP-sensitive K(+) (KATP) channel is an emerging pathway in the skeletal muscle atrophy which is a comorbidity condition in diabetes. The "in vitro" effects of the sulfonylureas and glinides were evaluated on the protein content/muscle weight, fibers viability, mitochondrial succinic dehydrogenases (SDH) activity, and channel currents in oxidative soleus (SOL), glycolitic/oxidative flexor d...

OBJECTIVE We tested the hypotheses that in nondiabetic individuals, partial inhibition of insulin secretion with the ATP-sensitive K(+) channel agonist (opener) diazoxide, compared with placebo, results in higher plasma glucose and higher plasma glucagon concentrations after a mixed meal and after administration of the sulfonylurea glimepiride. RESEARCH DESIGN AND METHODS Plasma glucose, insu...

BACKGROUND To evaluate the clinical efficacy of sitagliptin for reducing plasma glucose levels in Korean subjects with type 2 diabetes mellitus during a 14-week treatment period. METHODS Our study design involved the addition of 100 mg sitagliptin once-daily to three ongoing combination therapy regimens and changing from glimepiride and metformin to sitagliptin and metformin. RESULTS The ad...

S erum IGF-I is reduced in adolescents with type 1 diabetes, and injections of IGF-I improve glycemic control (1). The fact that sulfonylureas can increase IGF-I directly and independent of insulin has not been included in standard literature (2). The first observation of a stimulatory effect on serum IGF-I was made in hypophysectomized rats (3). In in vitro experiments, glibenclamide stimulate...

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

AIMS Glimepiride is a new sulfonylurea for diabetes treatment which is supposed to impact less on extra-pancreatic ATP-dependent K+ channels than the conventional drug glibenclamide. This study was performed to evaluate whether this results in a better maintenance of ATP-dependent K+ channel mediated ischaemic myocardial preconditioning. METHODS AND RESULTS In a double-blind placebo-controlle...

AIMS Patients with type 2 diabetes mellitus (T2DM) have increased risk of adverse events (AEs; e.g. dehydration, hypoglycaemia) in hot weather. This analysis assessed the efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, in patients with T2DM who live in hot climates. METHODS This post hoc analysis evaluated patients with T2DM using pooled data from fo...

The purpose of the research work was formulation development and evaluation bi-layer floating tablets for metformin hydrochloride and glimepiride to improve the oral therapeutic efficacy Both these drugs exhibit pH dependent solubility and show good permeability from stomach and upper part of the small intestine into systemic circulation. Direct compression method form metformin hydrochloride l...