Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection and xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin and casein) and ethyl mercury (xenobiotic) bind to different lymphocyte receptors and tissue enzyme (DPP IV or CD26)...

The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen which consistently separated 26 patients with untreated coeliac disease from 26 normal controls and 13 patients with chronic inflammatory bowel disease. The mean assay inde...

Gliadin due to its low water solubility is excellently suited make biopolymeric nanoparticles through liquid antisolvent precipitation. These gliadin (GNPs) can be utilized populate and stabilize interfaces. Gliadin, by nature a protein that carries charge, altered deamidation. Deamidation effectively alters the physicochemical properties of decreasing protein’s isoelectric point (IEP). The obj...

THE RELATIVE TOXICITY OF CHLOROFORM GIVEN SUBCUTANEOUSLY TO RATS FED ON TWO DIETS DEFICIENT IN RESPECT TO THEIR NITROGENOUS COMPONENTS, THE SOLE SOURCES OF PROTEIN IN WHICH WERE, RESPECTIVELY, GLIADIN AND GELATIN AND TO RATS WITHOUT FOOD, IS AS FOLLOWS: gelatin diet > fasting > gliadin diet. The rate of regeneration of liver cells after chloroform poisoning in rats fed a diet in which gliadin i...

BACKGROUND Multiple changes in antibodies against various antigens are found in multiple sclerosis (MS). OBJECTIVE We wanted to measure immunoglobulin A (IgA) antibodies to some common food antigens in MS and also IgG against gliadin and gluten. METHODS The IgA antibodies were measured in serum against gluten, gliadin, lactoglobulin, lactalbumin, casein and ovalbumin in patients with MS and...

Coeliac disease is an inflammatory disease of the small intestine caused by ingestion of wheat gluten or related proteins from rye or barley. In the small intestine, ingested gluten is broken down into gliadin peptides which are deamidated by the enzyme tissue transglutaminase (tTg) resulting in the substitution of glutamine amino acid residues with glutamic acid. These modified gliadin peptide...

Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were en...