introduction h istone deacetylase inhibitors (hdis), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...

objective: although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. it is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. there are controversies regarding sodium valproate efficacy in psychosis. although some studies have reported that it is effective in the ...

conclusions trichloroacetic acid and autologous fibroblast can be considered as therapeutic choice for recalcitrant diabetic foot ulcer. introduction foot ulcer, with a prevalence of 15% in general population, is one of the main complications in patients with diabetes. so far, different therapeutic methods have been provided for the treatment of foot ulcers. when no response to the standard tre...

background: l-glutamic acid is one of the major amino acids that is present in a wide variety of foods. it is mainly used as a food additive and flavor enhancer in the form of sodium salt. corynebacterium glutamicum (c. glutamicum) is one of the major organisms widely used for glutamic acid production. methods: the study was dealing with immobilization of c. glutamicum and mixed culture of c. g...

a new model is proposed in this research to calculate the longitudinal strengthof unidirectional e-glass reinforced polymer composites exposed to sulfuricacid environment, using a micromechanics model. in the proposed method,it is assumed that the residual strength of the degraded composites under acidic environment can be calculated by knowing the degraded strength properties of the constituen...

plants of asteraceae are used in traditional medicine and phytotherapy. the two main caffeic acid derivatives, chicoric and caftaric acid which are found in many genus of asteraceae including echinacea exhibit important biological activities. the level of these acids in e. purpurea is affected by many factors such as growing situations, extraction methods, storage conditions and plant age. in t...

introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose sei...