Multinucleated stromal giant cells were seen in the colonic mucosa in biopsy specimens from two patients with long-standing quiescent ulcerative colitis. Similar cells have been described at other sites associated with chronic inflammation, including the lower female genital tract, bladder and anus. The immunophenotype of the cells in the colonic mucosa suggested that they had originated from f...

Peripheral giant cell granulomas are common proliferative lesions of the oral cavity with a predilection for females. In this study, the presence of estrogen and progesterone receptors in 26 peripheral giant cell granuloma cases were studied utilizing the immunoperoxidase technique. In fourteen cases, estrogen receptor positivity was found in stromal cells. In ten of these, osteoclast-type gian...

This article describes a case of giant cell fibroma in a 3-year-old boy, which is an uncommon age for this lesion. The cause of this pathology has not been determined. The lesion was excised by electro surgery and submitted to a histological exam, which confirmed the diagnosis. No recurrence was observed. Pediatric dentists should be capable to diagnose and treat this kind of lesion despite thi...

Central giant cell granuloma (CGCG) is a relatively uncommon benign bony lesion of a variably aggressive nature. Thought to represent a reparative response to intrabony haemorrhage and inflammation, CGCG was once regarded as a reactive lesion. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible expansion of t...

We describe the case of a 35 years old man with a nonspecific complaint of a slow growing solid mass in the frontal region. Radiological exams evidenced two more lesions : in the superior and lateral walls of the orbit. Treated with total excision of the lesions and a cranioplastic procedure at the same act, with favorable outcome. Microscopic findings suggested giant cell tumor in the three le...

The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected ...

Figure 1. Intermediate-power microscopy shows the eosinophilic colloid-filled follicles at the periphery. In many follicles in the center, the epithelium has been replaced by the inflammatory reaction and the colloid is reduced or absent. Microabscess formation with foreign-body-type giant cells can be seen. Figure 2. A: The colloid is engulfed by the ring of foreign-body-type giant cells with ...

Multinucleated giant cells in the mouse testis after ligation of the efferent duct were examined by light and electron microscopy. The findings suggest that the giant cells are formed as a result of the fusion of spermatids due to alterations in the intercellular bridges. Further, the orientation of acrosomes, nuclei, and organelles for formation of the tail in the giant cells is related to the...

The ultrastructure of placental bed giant cells in early human pregnancies of 7-12 weeks gestational age is described. Their nature and function was further characterized by confocal immunofluorescence microscopy of paraffin sections labelled for cytokeratin, gap junction connexins (CX) 32 or 43, and placental hormones, alpha-human chorionic gonadotrophin (alpha-HCG) and human placental lactoge...