The abnormal pregnancies complete and partial hydatidiform mole are genetically unusual, being associated with two copies of the paternal genome. Typical moles (CHMs) diploid androgenetic, while (PHMs) diandric triploids. While diagnosis can usually be made on basis morphology, ancillary techniques that exploit their unusual genetic origin used to facilitate diagnosis. Genotyping p57 immunostai...

A complete hydatiform mole coexisting with a live, viable twin is a rare event. The diagnosis is challenging, and is normally achieved only at second trimester. It may be associated with thyrotoxicosis, vaginal bleeding, preeclampsia, fetal death or persistent throphoblastic disease. The authors describe the case of a pregnant woman presenting with first trimester bleeding. Ultrasound revealed ...

( Obstet Gynecol . 2021;137:355–370) Gestational trophoblastic disease (GTD) refers to rare processes originating from the placenta that require timely and appropriate management. GTD includes partial or complete hydatidiform moles (HM), as well severe gestational neoplasia (GTN) related tumors. Obstetrician-gynecologists are more likely be involved in care of women with HM who have unclear dia...

•We present two cases of postmolar gestational trophoblastic neoplasia (GTN).•Both cases presented with lung metastases after hydatidiform mole.•Both cases showed spontaneous regression without treatment.•The mechanism behind this phenomenon remains unclear.•Patients with postmolar GTN and declining hCG values may not need chemotherapy.

Invasive mole belongs to gestational trophoblastic neoplasm, which is a highly curable group of pregnancy-related tumors. However, approximately 20% of gestational trophoblastic tumors will be resistant to or relapsed after initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. It is still unclear which regimens are the most effecti...

•Gestational trophoblastic neoplasia can arise during the first trimester originating from trophoblasts of concurrent pregnancy.•Intraplacental choriocarcinoma can be developed from trophoblasts of a previous pregnancy.

We describe a case of choriocarcinoma in which increased concentrations of beta-choriogonadotropin subunits in serum indicated recurrence of metastasis long before the tumor could be confirmed by visualization techniques, while intact choriogonadotropin remained normal (less than 5 int. units/L). Therefore, detection or monitoring of choriocarcinoma requires the assay of free beta-hCG subunit o...