Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN). It most commonly occurs after a delivery but may arise after any type of pregnancy. PSTT arises after neoplastic transformation of intermediate trophoblastic cells. The most commonly reported symptoms are abnormal bleeding or amenorrhea. Due to the rarity of this disease, evidence on prognosti...

A G3P(1+1) who underwent dilatation and curettage (D and C) for persistent vaginal bleeding after a month of molar evacuation, underwent successful treatment of choriocarcinoma with methotrexate and was able to have normal baby weighing 2800 gms with good Apgar score and normal placenta. This shows that a normal menstruation and uncomplicated term delivery can be expected after complete chemoth...

BACKGROUND Gestational trophoblastic neoplasia (GTN) is a malignant disease which occurs in women of reproductive age. Treatment of GTN has an excellent outcome and further pregnancies can be expected. However, data concerning quality of life in these cancer survivor patients are limited. This study aimed to assess quality of life in women who were diagnosed with GTN and remission after treatme...

Gestational trophoblastic neoplasia (GTN) is a hemorrhagic malignancy with highly rapid potential metastasis via hematogenous spreading. Renal metastasis is of infrequent occurrence. Among previous case reports of renal metastasis in GTN, this is the youngest woman presenting a large renal lesion concurrent with pulmonary and brain metastases. Disease remission had been achieved by treatment wi...

A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on CHM genomic DNA identical to that of the paternal somatic cells. The developed in woman who had undergone intrauterine implantation blastocyst obtained through vitro injection presumed round spermatid into one her oocytes. was genetically peripheral white cells husband and contained no mate...

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and less frequently, the brain. Metastases to the kidney are rare in the literature, and bilateral involvement is even more scarce. Renal involvement of choriocarcinoma is highly exceptional and may mimic renal cell carcinoma. Here we report a case of bilater...

It is over 100 years since Felix Marchand identified choriocarcinoma as a tumor arising from placental villous trophoblast. In 1956, Hertz etal 1 first reported the cure of a patient with metastatic choriocarcinoma using chemotherapy. The next decade saw Hertz and colleagues at the National Institute of Health, Brewer in Chicago and Bagshawe in London develop the chemotherapeutic approach to ge...

Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early pre...

Various forms of trophoblastic diseases were reported in the literature, including complete and partial hydatidiform moles, gestational choriocarcinomas, placental-site epitheloid tumors. Among patients who suffer from mole, neoplasia can be easily diagnosed by using levels human chorionic gonadotropin (hCG). Therefore, complex investigations are not usually necessary measuring hCG, physical ex...