Purpose: The role of growth factors in ovarian cancer development and progression is complex and multifactorial. We hypothesized that new growth factors may be identified through the molecular analysis of ovarian tumors as they exist in their native environment. Experimental Design: RNA extracted from microdissected serous low malignant potential (LMP) and invasive ovarian tumors was used to co...

PURPOSE Multiple myeloma is an incurable malignant plasma cell disease characterized by survival ranging from several months to more than 15 years. Assessment of risk and underlying molecular heterogeneity can be excellently done by gene expression profiling (GEP), but its way into clinical routine is hampered by the lack of an appropriate reporting tool and the integration with other prognosti...

[1] Northern peatlands are likely to be important in future carbon cycle-climate feedbacks due to their large carbon pools and vulnerability to hydrological change. Use of non-peatland-specific models could lead to bias in modeling studies of peatland-rich regions. Here, seven ecosystem models were used to simulate CO2 fluxes at three wetland sites in Canada and the northern United States, incl...

PURPOSE As a result of various independently proposed nomenclatures and classifications, there is confusion in the diagnosis and prediction of biological behavior of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A comprehensive nationwide study is needed in order to understand the biological characteristics of GEP-NETs in Korea. MATERIALS AND METHODS We collected 4,951 pathology re...

Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients remains a challenge. Here, we evaluated the specific genes and molecular pathways associated wit...

Aberrant expression of the cell cycle kinase inhibitors, p16 and p21, has been associated with poor prognosis in a number of human malignancies. These proteins may also be involved in the development and progression of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The present study aimed to investigate protein levels of p16 and p21 in GEP-NETs and to evaluate their clinical significa...

RATIONALE The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS 1. An 82-year-old male presented with a lower esophageal mass. Positron emission tomography computed tomography (PET-CT) scan showed a lower esophagea...

In this study, the efficiency of neuro-fuzzy inference system (ANFIS) and genetic expression programming (GEP) in predicting the transfer length of prestressing strands in prestressed concrete beams was investigated. Many models suggested for the transfer length of prestressing strands usually consider one or two parameters and do not provide consistent accurate prediction. The alternative appr...

An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age- and sex-matched control group of patients with identical malignancies. The series comprised 243 men a...

Gene expression programming (GEP) is frequently used to create intelligent dispatching rules for job-shop scheduling. The proper selection of the terminal set a critical factor success GEP. However, there are various job features and machine that can be included in sets capture different characteristics state. Moreover, importance varies greatly between scenarios. irrelevant redundant may lead ...