In order to extract any ULF signature associated with earthquakes, the principal component analysis (PCA) and singular spectral analysis (SSA) have been performed to investigate the possibility of discrimination of signals from different sources (geomagnetic variation, artificial noise, and the other sources (earthquake-related ULF emissions)). We adopt PCA to the time series data observed at c...

There is concern regarding neurotoxicity induced by the use of local anesthetics. A previous study showed that an overload of intracellular calcium is involved in the neurotoxic effect of some anesthetics. T-type calcium channels, which lower the threshold of action potentials, can regulate the influx of calcium ions. We hypothesized that T-type calcium channels are involved in bupivacaine-indu...

Long records of teleseismic observations accumulated at permanent seismic stations Harvard, MA; Palisades, NY; and Standing Stone, PA, in eastern North America are inverted for vertical distribution of anisotropic parameters. High-resolution anisotropy-aware P wave receiver function analysis and multiple-layer core-refracted SKS waveform modeling favor more than one layer of anisotropy beneath ...

Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition. Herein, we innovatively established an artificial neural network cascade (NNC) model composed of 23 cascaded networks in a ladder-like...

Poultry meat is very susceptible to oxidation because of the high concentration of polyunsaturated fatty acids, which negatively affects the quality and nutritional values of chicken meat. Coccidiosis is the most common parasitic disease of poultry. Intending to limit anti-parasites usage in poultry feed and also because of the concerns about antibiotic resistance and residues in poultry produc...

Sphingosine kinase inhibitor (SKI) II has been reported as a dual inhibitor of sphingosine kinases (SKs) 1 and 2 and has been extensively used to prove the involvement of SKs and sphingosine-1-phosphate (S1P) in cellular processes. Dihydroceramide desaturase (Des1), the last enzyme in the de novo synthesis of ceramide (Cer), regulates the balance between dihydroceramides (dhCers) and Cers. Both...

The focus for information retrieval systems in digital libraries has shifted from passive repositories of information to recommendation systems that actively participate in retrieving useful information, and can furthermore learn from the retrieval behavior of users. We propose a novel evaluation methodology for such systems based on the concepts of shared knowledge structures, and system devel...