Melanocortin-3 receptor (MC3R) plays an important role in the central control of energy homeostasis, and several functional polymorphisms of this gene have been detected. We have studied MC3R as a candidate gene responsible for variation in economically important traits in chicken. To determine the association between MC3R polymorphism and phenotypic variation, a total of 190 individuals from b...

PURPOSE Cyclooxygenase (COX) is the main pharmacodynamic target of nonsteroidal anti-inflammatory drugs (NSAIDs). We investigated the inhibitory effects on COX-2 after NSAIDs administration using a lipopolysaccharide (LPS)-derived COX-2 induction model in whole blood, according to the genotypes of COX-2 single-nucleotide polymorphisms (SNPs). PATIENTS AND METHODS Seven genotypes of COX-2 SNPs...

Superior crop cultivars must be identified through multi-environment trials (MET) and on the basis of multiple traits. The objectives of this paper were to describe two types of biplots, the GGE biplot and the GT biplot, which graphically display genotype by environment data and genotype by trait data, respectively, and hence facilitate cultivar evaluation on the basis of MET data and multiple ...

BACKGROUND: Plasma levels of tumor necrosis factor (TNF)-alpha and of C-reactive protein (CRP) are elevated in smokers. Previous studies failed to show an association between the G-308A polymorphism in the promoter region of the TNF-alpha gene and coronary artery disease (CAD). We investigated whether smoking would interact with the TNF-alpha G-308A polymorphism in determining plasma levels of ...

BACKGROUND Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation responses to infection, which may control HPV clearance. We thus hypothesized that microRNA polymorphisms modify the association between HPV16 seropositivity and OS...

Genotype main effect and genotype by environment interaction biplot analysis is the best fit model for which-won-where pattern analysis, genotype, test evaluation. Hence, aim of this study was to identify stable high-yielding soybean genotypes production in diverse environments using stability model. Eighteen were evaluated across six during 2019 cropping season a randomized complete block desi...

OBJECTIVE Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism. METHO...