A set of new data types emerged from functional genomic assays, including ChIP-seq, DNase-seq, FAIRE-seq and others. The results are typically stored as genome-wide intensities (WIG/bigWig files) or functional genomic regions (peak/BED files). These data types present new challenges to big data science. Here, we present GeNemo, a web-based search engine for functional genomic data. GeNemo searc...

Increased drought frequency due to climate change is limiting the agronomic performance of cereal crops globally, where cultivars often experience negative impacts on yield. Stomata are living interface responsible for >90% plant water loss through transpiration. Thus, stomata a prospective target improving tolerance by enhancing water-use efficiency (WUE) in economically important cereals. ...

ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status leads to epigenetic modification, genomic instability, initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes activate oncogenes, enabling cells have cancer promoting properties. The nuclear factor erythroid 2-related 2 (Nrf2) is a transcription that in h...

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against g...

objective: this study determined the chromosomal constitution of recurrent spontaneous abortions by comparative genomic hybridization (cgh) analysis of fetal samples. material and methods:   forty pregnant women with early recurrent pregnancy losses aged 21 to 42 years old from tehran university of medical sciences affiliated hospitals entered in this descriptive study. hibridization analysis o...

Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet.

Early biochemical experiments measuring nearest neighbor frequencies established that the set of dinucleotide relative abundance values (dinucleotide biases) is a remarkably stable property of the DNA of an organism. Analyses of currently available genomic sequence data have extended these earlier results, showing that the dinucleotide biases evaluated for successive 50 kb segments of a genome ...

Detailed genomic contact maps have revealed that chromosomes are structurally organized in megabase-sized topologically associated domains (TADs) that encompass smaller subTADs. These domains segregate in the nuclear space to form active and inactive nuclear compartments, but cause and consequence of compartmentalization are largely unknown. Here, we combined lacO/lacR binding platforms with al...

Histone modifications are important markers of function and chromatin state, yet the DNA sequence elements that direct them to specific genomic locations are poorly understood. Here, we identify hundreds of quantitative trait loci, genome-wide, that affect histone modification or RNA polymerase II (Pol II) occupancy in Yoruba lymphoblastoid cell lines (LCLs). In many cases, the same variant is ...

Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. In mice, piRNA-guided tran...