Metabolic diversity in microorganisms can provide the basis for creating novel biochemical products. However, most metabolic engineering projects utilize a handful of established model organisms and thus, a challenge for harnessing the potential of novel microbial functions is the ability to either heterologously express novel genes or directly utilize non-model organisms. Genetic manipulation ...

Spatially Selective Assembly of Quantum Dot Light Emitters in an LED via Decorating with Engineered Peptides Hilmi Volkan Demir, Urartu Ozgur Safak Seker, Gulis Zengin, Evren Mutlugun, Emre Sari, Candan Tamerler 2, , and Mehmet Sarikaya Department of Electrical and Electronics Engineering, Department of Physics and UNAM Institute of Material Science and Nanotechnology, Bilkent University, 06800...

Evolutionary engineering, which uses laboratory evolution to select for industrially relevant traits, is a popular strategy in the development of high-performing yeast strains for industrial production of fuels and chemicals. By integrating whole-genome sequencing, bioinformatics, classical genetics and genome-editing techniques, evolutionary engineering has also become a powerful approach for ...

The paper is dealing with new object-oriented concept of the mechatronics modelling methodology, focusing to the early design phase. The idea is based on the artificial intelligent methods, particularly genetics algorithms. Genetic algorithms are used to calculate different solution for given problem. The engineering problem is defined by Unified Modelling Language. The aim of the developed met...

Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have been used to induce efficient gene targeting. Engineering highly specific, dedicated DNA endonucleases is the key to a wider usage of this technology. In this study, we present two novel, chimeric ...

1. Department of Biology, MIT, Cambridge MA 2. Program in Computational and Systems Biology, MIT, Cambridge MA 3. Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 4. Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 5. Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jo...

Silvia A Arredondo, Tiffany F Chen, Austen F. Riggs, Hiram F Gilbert*, and George Georgiou 2, 3, 4 Departments of Chemical Engineering Biomedical Engineering, Molecular Genetics and Microbiology, Institute for Cell and Molecular Biology and Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, TX 78712; and *Department of Biochemistry, Baylor College of Medicine, ...

1 Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 2 Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3 Percuros B.V., Department of Developmental Bio-Engineering, University of Twente, Enschede, Netherlands, 4 Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands,...

Recent progress in molecular biology and genetics opens up the possibility of engineering a variety of biological systems, from single-cellular to multicellular organisms. The consortia of microbes that reside on the human body, the human-associated microbiota, are particularly interesting as targets for forward engineering and manipulation due to their relevance in health and disease. New tech...

Fatemeh Ajalloueian1,2, Moa Fransson3, Hossein Tavanai1, Mohammad Massumi4, Jöns Hilborn2, Katarina Leblanc5, Ayyoob Arpanaei6* and Peetra U Magnusson3* 1Department of Textile Engineering, Center of Excellence in Applied Nanotechnology, Isfahan University of Technology, Isfahan, 84156-83111, Iran 2Polymer Chemistry, Department of Chemistry, Ångström Laboratory, SciLife Lab, Uppsala University, ...