نتایج جستجو برای: genetic linkage analysis
تعداد نتایج: 3297133 فیلتر نتایج به سال:
Vesicoureteral reflux (VUR) (OMIM %193000), a common cause of childhood renal failure, is strongly influenced by hereditary factors. Familial VUR most closely conforms to autosomal-dominant inheritance, but because of variable penetrance and expressivity, large multigenerational pedigrees tractable to linkage analysis have been difficult to ascertain. A single genome-wide study of familial VUR ...
جنس کلئوم متعلق به خانواده کور (capparaceae) می باشد. در بررسی این جنس در خراسان 7 گونه یافت شده است . تاکساهای مذکور به منظور تعیین ویژگیهای تشریحی مورد مطالعه قرار گرفتند. هدف دیگر این پژوهش مطالعه جنس کلئوم با استفاده از روش تاکسونومی عددی می باشد. داده ها (ویژگیهای تشریحی) توسط سه روش تجزیه ای خوشه ای complete linkage, single linkage, average linkage آنالیز شدند. نتایج این بررسی مطالعات تاک...
Genome scan meta-analysis (GSMA) can prove very useful in detecting genetic effects too small to be detected in an individual linkage study and can also lead to more consistent results. In this paper, we propose a new kernel-based estimation procedure for GSMA. Instead of estimating identity by descent between markers, as performed in interval mapping approaches, we estimated directly the nonpa...
BACKGROUND Many traits differ by age and sex in humans, but genetic analysis of gene expression has typically not included them in the analysis. METHODS We used Genetic Analysis Workshop 15 Problem 1 data to determine whether gene expression in lymphoblasts showed differences by age and/or sex using generalized estimating equations (GEE). We performed quantitative trait linkage analysis of th...
We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, and association only tests under this framework. We also compared these results with variance-component linkage analysis and regression analys...
The increasing number of DNA polymorphisms characterized in humans will soon allow the construction of fine genetic maps of human chromosomes. This advance calls for a reexamination of current methodologies for linkage analysis by the family method. We have investigated the relative efficiency of two-point and three-point linkage tests for the detection of linkage and the estimation of recombin...
The moss Physcomitrella patens is a model for the study of plant cell biology and, by virtue of its basal position in land plant phylogeny, for comparative analysis of the evolution of plant gene function and development. It is ideally suited for 'reverse genetic' analysis by virtue of its outstanding ability to undertake targeted transgene integration by homologous recombination. However, gene...
Schizencephaly is a human brain malformation distinguished by full-thickness unilateral or bilateral clefts through the neocortex. Heterozygous mutations in the EMX2 locus are reported to give rise to schizencephaly. However, the comprehensive identification of causative genetic loci is precluded by a lack of large pedigrees and genome-wide linkage analyses. We present here a large Turkish pedi...
Association mapping is a technique with high resolution for QTL mapping based on linkage disequilibrium and has shown more promising for describing genetically complex traits. In addition, it is a powerful tool for describing complex agronomic traits and identifying alleles that can contribute to enhance the desired traits. In this study, whole genome association mapping was used in a set of 14...
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