microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from double-stranded hairpin precursors. They negatively regulate gene expression in animals, by binding, with imperfect base pairing, to target sites in messenger RNAs (usually in 3' untranslated regions) thereby either reducing translational efficiency or determining transcript degradation. Considering that e...

It is widely recognized nowadays that complex diseases are caused by, amongst the others, multiple genetic factors. The recent advent of genome-wide association study (GWA) has triggered a wave of research aimed at discovering genetic factors underlying common complex diseases. While the number of reported susceptible genetic variants is increasing steadily, the application of such findings int...

Screening for genetic diseases is performed in many regions and/or ethnic groups where there is a high prevalence of possibly malign genes. The propagation of such genes can be considered a dynamic externality. Given that many of these diseases are untreatable and give rise to truly tragic outcomes, they are a source of societal concern, and the screening process should perhaps be regulated. Th...

Primary osteoporosis is the disease’s most common form and results from the progressive loss of bone mass related to aging and unassociated with other illness, a natural process in adult life; its etiology is considered multifactorial and polygenic. This form currently represents a growing worldwide health problem due in part, to the contemporary environmental condi‐ tions of modern civilizatio...

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The paper offers an overview of quantum and macro gravity, two of the three pillars of the Grand Unified Theory (GUT), the other thermodynamics, developed in a series of papers since the solution of the gravitational n-body problem in 1997 (J. Nonlinear Analysis, A-Series: Theory, Methods and Applications, Vol. 30, No. 8, 1997, pp. 5021-5032) and consolidated in the paper, The Grand Unified The...

normal 0 false false false en-us x-none fa background:  regarding the importance of right diagnosis in medical applications, various methods have been exploited for processing medical images solar. the method of segmentation is used to analyze anal to miscall structures in medical imaging. objective:  this study describes a new method for brain magnetic resonance image (mri) segmentation via a ...