We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau-Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in slow wave sleep (ESES). T...

Background Epilepsy is among the most common neurological disorders in childhood, prevalence of which is increasing. Unpredictable and chronic nature of the disease affects physical, social and mental functions of the children and their family. This study was aimed to compare behavioral problems in epileptic children group versus healthy control group. Materials and Methods This study is a cas...

Background: Headache and epilepsy are two common chronic and recurrent disorders. Headache may be a premonitory or postdromic symptom of epileptic seizures. Objective: This study aims to evaluate the prevalence of migraine and tension type headache in epileptic patients. Materials and Methods: In a cross-sectional descriptive study, 100 patients with epilepsy who referred to the neurology clini...

A review of patients with epilepsy showed that 5.9% had seizures exclusively in sleep (ES) and 4.7% had seizures predominantly but not exclusively in sleep (PS). These groups were compared with a group (W) with seizures mainly in wakefulness. The following significant differences were obtained: 1) generalized convulsions predominated in the ES while partial seizures were more common among PS an...

objective: to investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among iranian patients before and after sodium valproate treatment.   patients and methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. serum antinuclear antibodies (ana), anti-cardiolipin antibodies (acl), a...

Epilepsy is a common neurological disorder with an incidence of approximately 0.5%. In order to develop better strategies for treatment of epilepsy, more insight on the etiology and pathogenesis of epilepsy is required. In 2001, based on the diagnostic scheme of the International League Against Epilepsy, three new forms of familial epilepsy were identified. These include familial temporal lobe ...

This article presents the updated, modified classification and definitions of epileptic syndromes, proposed by consensus International League Against Epilepsy (ILAE) task force. The ILAE report suggests a nosological revision epilepsy syndromes with onset in childhood, which are subdivided into three categories: (1) self-limited focal epilepsies; (2) genetic generalized (3) developmental and/or...

OBJECTIVE To study the electroclinical phenotype in 5 patients with large supernumerary marker chromosome referred as inv dup (15), in an attempt to analyze the electroclinical spectrum in order to determine if the binomial epilepsy-EEG is stereotyped enough to corroborate this challenging diagnosis. METHODS Five patients with large inv dup (15) were submitted to EEG and/or V-EEG, with a mini...

Epilepsy is a chronic neurological disorder which is manifested at some times and masked at others. Sleep-waking state physiology is one of the most well documented factors affecting the clinical expression or suppression of human epilepsy . Specifically, non-rapid-eye-movement (NREM) sleep and the gradual process of awakening from NREM sleep are the most vulnerable periods for seizures, especi...

Vagal nerve stimulation is approved for medically refractory partial epilepsy in children older than 12 years of age. However, it has been shown in the literature that vagal nerve stimulation is also quite efficacious in children younger than 12 with generalized epilepsy and brain malformations. We report a case series of children younger than 12 who responded well to vagal nerve stimulation. A...