silver salts and nanosilver (ns) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. therefore, in this study, the possible dermal toxicity of ns particles and silver nitrate (agno3), was tested by determining the serum level of transforming growth factor-β1(tgf-β1) and study on of mouse skin tissue. in this study, 30 balb...

Background and objectives: Scrophularia umbrosa Dumort is used as a traditional herb in China. In this study, chemical profile, free radical suppression capability, general toxicity and cardiovascular activities of the volatile compounds from S. umbrosa were investigated. Moreover, methanol (MeOH) extract of rhizomes were analyzed to purify and identify the constituents. Methods: GC/MS was used...

Aim of the study: The present study was carried out to evaluate the safety of ethanolic extract of celtis timorensis (EECT) by acute and sub-acute toxicity studies. Materials and Methods: Acute toxicity study was conducted in mice by using OECD 425 guidelines whereas sub-acute toxicity study was carried out in rats by using OECD 407 guidelines. In the acute toxicity study, mice were administere...

Various organic compounds used as diluents, modifiers and extractants in lactic acid extraction have been tested to determine their toxicity towards Lactobacillus casei cells. The toxicity on molecular and phase level has been investigated. In general, the tested hydrocarbons were non-toxic on molecular level and showed variable toxicity on phase level. Among the tested alcohols octanol and ole...

In general, much greater doses of local anesthetics are required to produce cardiovascular (CV) toxicity than CNS toxicity. Similar to CNS toxicity, potency for CV toxicity reflects the anesthetic potency of the agent. Recent attention has focused on the apparently exceptional cardiotoxicity of the more potent, more lipid-soluble agents (bupivacaine, levo-bupivacaine, etidocaine, ropivacaine). ...

Although it is not yet possible to replace in vivo animal testing completely, the need for a more efficient method for toxicity testing, such as an in vitro cell-based assay, has been widely acknowledged. Previous studies have focused on mRNAs as biomarkers; however, recent studies have revealed that non-coding RNAs (ncRNAs) are also efficient novel biomarkers for toxicity testing. Here, we use...

introduction: dentists are exposed to mercury vapor from dental amalgam in their routine occupational practice; excess exposure to mercury is harmful. the aim of this study was to assess the influence of some possible related factors on the urine mercury levels of general dentists and restorative specialists in mashhad in 2010. materials and methods: this cross-sectional study was performed ran...