T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; they also have developmental pathways with many parallels. Shared usage of basic helix-loop-helix E proteins as transcriptional drivers underlies these common features. However, the transcription factor networks in which these E proteins are embedded are different bo...

We describe a system that allows customers to interactively select, assemble, and modify 3D products over the WWW, enhancing the usage of 3D techniques for e-business. It provides a framework for a web-based 3D assembling system that can significantly simplify the assembling process while retaining enough flexibility to build an approximate model of real products. The assembled object is captur...

While genome sequencing projects are advancing rapidly, EST sequencing and analysis remains a primary research tool for the identification and categorization of gene sequences in a wide variety of species and an important resource for annotation of genomic sequence. The TIGR Gene Indices (http://www.tigr.org/tdb/tgi. shtml) are a collection of species-specific databases that use a highly refine...

Interface-binding enzymes are desirable for biphasic reactions in that they offer simultaneous access to substrates dissolved in both phases across the interface. It has been shown that conjugating water-soluble enzymes with hydrophobic polymers facilitated the assembling of enzymes at oil/water interfaces. In this work, the interfacial assembling of alpha-chymotrypsin conjugated with polystyre...

One of the grand challenges of robotics is the design of robots that are adaptive and self-sufficient. This can be crucial for robots exposed to environments that are unstructured (in space and time) or not easily accessible for a human operator, such as the inside of a blood vessel, a collapsed building, the deep sea, or the surface of another planet.Modular reconfigurable robots are among the...

Text mining approaches can accelerate the process of assembling knowledge from literature. In this abstract, we present our effort in assembling a resource for protein mutationdisease relations assembled from literature. Keywords—literature mining; protein mutation-disease

The advent of new genome sequencing platforms in 2005, generally named nextgeneration sequencers (NGS), has boosted the number of complete genomes deposited in public databases, mainly due to the ability of those platforms to generate a huge volume of genomic data in a faster and cheaper fashion than the previous methodologies. Concomitantly, gene expression analyses have also been favored due ...

Ferritins are ideal nanoparticles as drug delivery systems due to their hollow-sphere structure and the ability target specific receptors on cell surface. Here, we develop characterize a new ferritin derived from chimeric humanized A. fulgidus one, already designed recognize TfR1 receptor. Starting synthetic gene of this protein, replaced two positively charged amino acids with alanine residues...