All regulatory organizations are paying close attention to the identification and measurement of genotoxic contaminants. Using conventional analytical techniques like high-performance liquid chromatography (HPLC) gas quantify probable substances (PGIs) at trace level is difficult (GC). Therefore, there a necessity for advanced development highly sensitive procedures determination trace-level PG...

BACKGROUND Bombax ceiba Linn., commonly called as Semal, is used in various gastro-intestinal disturbances. It contains Lupeol which inhibits PTP-1B, adipogenesis, TG synthesis and accumulation of lipids in adipocytes and adipokines whereas the flavonoids isolated from B. ceiba has FAS inhibitory activity. The present study was aimed to investigate ameliorative potential of Bombax ceiba to expe...

This subteam under the Drug Metabolism Leadership Group (Innovation and Quality Consortium) investigated the quantitative role of circulating inhibitory metabolites in drug-drug interactions using physiologically based pharmacokinetic (PBPK) modeling. Three drugs with major circulating inhibitory metabolites (amiodarone, gemfibrozil, and sertraline) were systematically evaluated in addition to ...

Bahareh Abtahi-Naeini, Hamidreza Sadeghiyan1, Neda Adibi2, Mohammad Reza Shokrollahi3, Mohsen Pourazizi4 Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, 1Department of Dermatology, Isfahan University of Medical Sciences, 2Department of Dermatology, Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, ...