Poor bioavailability of Docetaxel (DCT) arising due to its low aqueous solubility and permeability limits its clinical utility. The aim of the present study was to develop DCT loaded self-emulsified drug delivery systems (D-SEDDS) and evaluate its potential ability to improve the oral bioavailability and therapeutic efficacy of DCT. D-SEDDS were characterized for their in vitro antitumor activi...

The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. The effect of different surfactants such as gelucire 44/14, poloxamer 188, poloxamer 407, Ryoto sugar ester L1695, and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation and dissolu...

Stratigraphic data from salt marshes provide accurate reconstructions of Holocene relative sea-level (RSL) change and necessary constraints to models glacial isostatic adjustment (GIA), which is the dominant cause Late-Holocene RSL rise along U.S. mid-Atlantic coast. Here, we produce a new Mid- record marsh bordering Great Bay in southern New Jersey using basal peats. We use multi-proxy approac...

The high resolution spectrograph ESPRESSO on the VLT allows measurements of fundamental constants at unprecedented precision and hence enables tests for spacetime variations predicted by some theories. In a series recent papers, we developed optimal analysis procedures that both exposes eliminates subjectivity bias in previous quasar absorption system measurements. this paper analyse spectrum z...

The proton pumping H(+)-ATPase, Pma1p, is an abundant and very long-lived polytopic protein of the Saccharomyces cerevisiae plasma membrane. Pma1p constitutes a major cargo of the secretory pathway and thus serves as an excellent model to study plasma membrane biogenesis. We have previously shown that newly synthesized Pma1p is mistargeted to the vacuole in an elo3Delta mutant that affects the ...

The study has been carried out to determine the frequency of C. difficile recovery in stool cultures and the rate of C. difficile toxin A detection in faecal specimens of patients with nosocomial diarrhoea. Clinical specimens comprised 4414 stool samples collected from 1998 to 2002 from adult patients hospitalised in different wards of a university-affiliated hospital (1200 beds) and suspected ...

Many-multiplet (MM) method [1] applied to three inhomogeneous samples of Keck/HIRES quasar absorption spectra gives a shift in the value of the fine-structure constant of ∆α/α = (−5.4± 1.2)× 10−6 in the redshift range 0.2 < z < 3.7 [2]. The 1 σ error claimed in [2] is, however, much too small and cannot be maintained by current observations of quasars. We present a modified MM method to set an ...

Detailed analysis of the spectral lines from two low redshift damped Lyman alpha absorbers (DLA) confirms that they are a heterogeneous population. Both systems have low metal abundances of approximately 0.05 to 0.1 solar. The abundance pattern of the DLA at z = 1.15 towards HE 0515-4414 shows dust depletion comparable to that found in our Galaxy, while the system at z = 0.68 towards HE 1122-16...

Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide...