The Good Clinical Practices (GCP) codes of the WHO and the International Conference of Harmonization set international standards for clinical research. But critics argue that they were written without consideration for the challenges faced in low and middle income countries (LMICs). Based on our field experience in LMICs, we developed a non-exhaustive set of recommendations for the improvement ...

Quality and ethics need to be embedded into all areas of research with human participants. Good Clinical Practice (GCP) guidelines are international ethical and scientific quality standards for designing, conducting, recording and reporting trials involving human participants. Compliance with GCP is expected to provide public assurance that the rights, safety and wellbeing of participants are p...

Good clinical practice (GCP) guidelines should always be implemented and obeyed in clinical interventional studies. In this mini-review, we will address several burning questions relating to GCP in a concise 'frequently asked questions' format. While compliance to current rules and regulations is our mission, we also wish to play devil's advocate attempting to translate the rules into sizeable ...

Denoising and demosaicking are essential yet correlated steps to reconstruct a full color image from the raw filter array (CFA) data. By learning deep convolutional neural network (CNN), significant progress has been achieved perform denoising jointly. However, most existing CNN-based joint (JDD) methods work on single while assuming additive white Gaussian noise, which limits their performance...

In this work, we focus on the problem of selecting low-level heuristics in a hyperheuristic approach with offline learning, for solution instances different domains. The objective is to improve performance approach, identifying equivalence classes set problems and best performing each them. A methodology proposed as first step all problems, generic characteristics instance one them are consider...

Randomised controlled trials form the foundation for ‘evidence-based-medicine’, but the results of such research can be relied upon only if it was conducted according to principles and standards collectively referred to as ‘Good Clinical Practice’ (GCP). The GCP was established as a basis both for the scientific and ethical integrity of research involving human subjects and for generating valid...

Gastritis cystica polyposis (GCP) is a rare benign hyperplastic polypoid neoplasm that usually occurs on the gastric side of anastomoses in patients who have previously undergone gastroenterostomy surgery. Only few cases GCP been reported unoperated stomach. Here we present 73-year-old female investigation for altered bowel habits was found to polyp diagnosed as GCP. Both endoscopic and radiolo...

AIM The aim of this case-series study is to evaluate the prevalence of mucositis, peri-implantitis, and survival and success rates of oxide-coated implants in subjects treated for periodontitis. MATERIALS AND METHODS Twenty-four subjects treated for generalized chronic periodontitis (GCP) and five treated for generalized aggressive periodontitis (GAP) were orally rehabilitated with a total of...

We extend the previously developed geometrical correction for the inter- and intramolecular basis set superposition error (gCP) to periodic density functional theory (DFT) calculations. We report gCP results compared to those from the standard Boys-Bernardi counterpoise correction scheme and large basis set calculations. The applicability of the method to molecular crystals as the main target i...