Gastroesophageal reflux (GER) occurs in 2 distinct forms that differ in pathophysiology, clinical presentation, natural history, and therapy: mild GER (with no or minimal esophagitis) and classic, severe reflux (at risk for erosive esophagitis). A minority of subjects (< 20%) have the classic, potentially severe pattern of GER caused by reduced lower esophageal sphincter (LES) pressure and prol...

BACKGROUND AND PURPOSE Contrast-enhanced head and neck MRA may be degraded by venous stasis and reflux of contrast into the jugular veins. The purpose of this study was to evaluate the relationship between venous stasis and reflux and the side of injection and other causal factors. MATERIALS AND METHODS One hundred twenty-six consecutive patients (94 males and 32 females) who underwent contra...

BACKGROUND Data on acid and non-acid reflux patterns and esophageal function in Japanese patients with non-erosive reflux disease (NERD) are limited. The aim of this study was to use combined multichannel intraluminal impedance pH monitoring (MII-pH) and high-resolution manometry (HRM) to investigate the characteristics of Japanese patients who were treated with a "double-dose" (20 mg) of rabep...

Data on the natural course of gastrooesophageal reflux disease are sparse. One hundred and sixty six patients with typical reflux symptoms (heartburn and/or acid regurgitation) and pathologic pH monitoring (reflux time > 8.2% upright and/or > 3.0% supine) were studied. The patients were followed up by questionnaire and interview for a mean of 41 (seven to 86) months after diagnosis of reflux di...

PURPOSE Gastro-esophageal reflux (GER), particularly non-acid reflux, is common in infants and is a known cause of chronic respiratory symptoms in infancy. Recent guidelines recommended empirical acid suppression therapy and the head-up position in patients with suspected GER. However, the efficacy of the upright position in relieving GER and reflux-related respiratory symptoms in infants is un...

CONTEXT Laryngopharyngeal reflux (LPR) is a major cause of laryngeal inflammation and presents with a constellation of symptoms different from classic gastroesophageal reflux disease. OBJECTIVE To provide a practical approach to evaluating and managing cases of LPR. EVIDENCE ACQUISITION The PubMed database and the Ovid Database of Systematic Reviews were systematically searched for laryngop...

introduction: this study evaluates the accuracy of renal ultrasonography (us) in the detection of vesicoureteral reflux (vur) compared to voiding cystourethrography (vcug). methods: we retrospectively reviewed the medical records of 131 children with urinary tract infection. ultrasound findings were considered to be suggestive of vur if a “pelvocalyceal dilatation”‚ “retrovesical ureteral dilat...

Objective-comparative evaluation of different surgical methods of vesicoureteral reflux induction in rabbits.Design- Elective experimental study.Animals- sixteen healthy male rabbits.Procedures- sixteen healthy NewZiland White male rabbits were randomly divided in four equal groups. All rabbits were preoperatively evaluated with retrograde cystography for the presence or absence of congenital o...

AIMS The primary aim was to assess whether there were differences in symptoms, laboratory data, and oesophageal pH-metry between infants with primary gastro-oesophageal reflux and those with reflux secondary to cows' milk protein allergy (CMPA). PATIENTS AND METHODS 96 infants (mean(SD) age 7.8(2.0) months) with either primary gastro-oesophageal reflux, reflux with CMPA, CMPA only, or none of...

BACKGROUND The role of bile in the genesis of oesophageal symptoms and disease is incompletely understood. A new method of ambulatory bile monitoring may help to define this role. AIMS To establish the relationship between symptom events and acid and bile reflux episodes. PATIENTS 59 consecutive patients presenting for further investigation of gastro-oesophageal reflux disease. METHODS Al...