نتایج جستجو برای: gap junction

تعداد نتایج: 185750  

Journal: :Methods 2000
M M Falk

For gap junction channels to function, their subunit proteins, referred to as connexins, have to be synthesized and inserted into the cell membrane in their native configuration. Like other transmembrane proteins, connexins are synthesized and inserted cotranslationally into the endoplasmic reticulum membrane. Membrane insertion is followed by their assembly and transport to the plasma membrane...

Journal: :The Journal of biological chemistry 2005
Chih-Jen Wei Richard Francis Xin Xu Cecilia W Lo

Previous studies have indicated an intimate linkage between gap junction and adherens junction formation. It was suggested this could reflect the close membrane-membrane apposition required for junction formation. In NIH3T3 cells, we observed the colocalization of connexin43 (Cx43alpha1) gap junction protein with N-cadherin, p120, and other N-cadherin-associated proteins at regions of cell-cell...

2013
Wei-Pang Chang José Jiun-Shian Wu Bai-Chuang Shyu

The thalamus is an important target for deep brain stimulation in the treatment of seizures. However, whether the modulatory effect of thalamic inputs on cortical seizures occurs through the modulation of gap junctions has not been previously studied. Therefore, we tested the effects of different gap junction blockers and couplers in a drug-resistant seizure model and studied the role of gap ju...

Journal: :Cancer research 1999
W Zhang W T Couldwell M F Simard H Song J H Lin M Nedergaard

Gap junctions are intercellular channels that connect the interiors of coupled cells. We sought to determine the extent to which malignant glioma cells form gap junction channels with astrocytes from either adult human brain or rat forebrain. The astrocytic gap junction protein, connexin 43 (Cx43), was identified in immunoreactive plaques at areas of cell-to-cell contact between cocultured glio...

2016
Haicheng PIAN

Tendons are mostly composed of collagen fibers and transmit forces from muscle to bone. Tenocytes are cells in tendon that produce main constituent of tendon such as type I collagen, and are linked each other via gap junctions at cell-cell junctions. Most cells in normal tissues generally communicate via gap junction. For example, ion and small molecule movements through the gap junction channe...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1994
P B Guthrie R E Lee V Rehder M F Schmidt S B Kater

Electrical coupling between specific neurons is important for proper function of many neuronal circuits. Identified cultured neurons from the snail Helisoma show a strong correlation between electrical coupling and presence of gap junction plaques in freeze-fracture replicas. Gap junction plaques, however, were never seen between overlapping neurites from a single neuron, even though those same...

Journal: :The Journal of endocrinology 2005
Ferng-Chun Ke Su-Huan Fang Ming-Ting Lee Shiow-Yhu Sheu Si-Yi Lai Yun Ju Chen Fore-Lien Huang Paulus S Wang Douglas M Stocco Jiuan-Jiuan Hwang

The present study was designed to explore the role of gap junctions in follicle-stimulating hormone (FSH) and transforming growth factor beta1 (TGF beta1)-stimulated steroidogenesis in ovarian granulosa cells of gonadotropin-primed immature rats. There were three specific aims. First, we investigated the effect of FSH and TGF beta1 as well as lindane (a general gap junction blocker) on the leve...

Journal: :The Journal of Cell Biology 1997
Niklas R. Jørgensen Steven T. Geist Roberto Civitelli Thomas H. Steinberg

Many cells coordinate their activities by transmitting rises in intracellular calcium from cell to cell. In nonexcitable cells, there are currently two models for intercellular calcium wave propagation, both of which involve release of inositol trisphosphate (IP3)- sensitive intracellular calcium stores. In one model, IP3 traverses gap junctions and initiates the release of intracellular calciu...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2008
Rahul J Anand Shipan Dai Christopher Rippel Cynthia Leaphart Faisal Qureshi Steven C Gribar Jeff W Kohler Jun Li Donna Beer Stolz Chhinder Sodhi David J Hackam

Enterocytes exist in close association with tissue macrophages, whose activation during inflammatory processes leads to the release of nitric oxide (NO). Repair from mucosal injury requires the migration of enterocytes into the mucosal defect, a process that requires connexin43 (Cx43)-mediated gap junction communication between adjacent enterocytes. Enterocyte migration is inhibited during infl...

Journal: :Medical hypotheses 2006
Somayeh Mahdavi Mostafa Rezaei-Tavirani Shahriar Gharibzadeh Farzad Towhidkhah

Two main mechanisms have been suggested for the propagation of action potentials in cardiac muscle cells: (1) the free flow of local circuit current through gap junctions and (2) the effect of electrical field. Different evidences confirm each of two mechanisms. We think that gap junctions are not continuously open in a normal heart cycle; instead, they open and close intermittently. In other w...

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