We established an improved method for the generation of mouse monoclonal antibodies (MAbs) to gangliosides by immunizing mice with purified gangliosides. Using this method, we generated and characterized a large number of the MAbs specific for gangliosides. These MAbs enabled us to examine the distribution of ganglioside in the brain. Immunohistoand immunocyto-chemical studies suggested that th...

Cerebellar degeneration has been associated with gluten sensitivity and celiac disease. Patients with celiac disease may have neuropathy and antibodies to gangliosides. The authors investigated the presence of antiganglioside antibodies in 22 patients with hereditary and nonhereditary ataxia and found 64% reactive in a novel agglutination test.

After 10 years of clinical trials in patients with advanced cancer, monoclonal antibodies (mAbs) against cell surface antigens have not lived up to their initial promise. One such cell surface antigen is the ganglioside GD2. GD2 is richly expressed at the cell surfaces of human neuroblastomas, sarcomas, and melanomas. We have described a murine lymphoma (EL4) that is syngeneic in C57BL/6 mice a...

After 10 years of clinical trials in patients with advanced cancer, monoclonal antibodies iniAhsi against cell surface antigens have not lived up to their initial promise. One such cell surface antigen is the ganglioside GD2. GD2 is richly expressed at the cell surfaces of human neuroblastomas, sarcomas, and melanomas. We have described a murine lymphoma (EL4) that is syngeneic in C57BL/6 mice ...