Radiosurgery is a therapeutic technique to deliver high dose radiation to the target. It induces radiobiological responses of lesions while minimizing radiation effect to the surrounding area. Gamma knife is one of the representative devices for stereotactic radiosurgery, which is exclusively designed for treatment of cerebral disorders. Gamma knife was developed as the first radiosurgical devi...

Radiosurgery is defined as the use of highly focused beams of radiation to ablate a pathologic target, thus achieving a surgical objective by noninvasive means. Recent advances have allowed a wide variety of intracranial lesions to be effectively treated with radiosurgery, and radiosurgical treatment has been accepted as a standard part of the neurosurgical armamentarium. The advent of frameles...

Image guided brain surgery became a reality in the mid-1970s after the introduction of the fi rst methods to obtain axial imaging using computed tomography (CT) [9]. The recognition of cranial disease much earlier in its clinical course prompted the need for concomitant minimally invasive technologies to both diagnose and to treat the newly recognized brain tumors and vascular malformations. Su...

OBJECTIVE To study the clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy (MTLE) and their effects on EF-Tumt and EF-Tsmt expression. PATIENTS AND METHODS The data of 78 cases of MTLE patients treated in our hospital from April 2011 to March 2013 were retrospectively analyzed. The patients were divided into two groups according to the treatment methods: th...

BACKGROUND The etiology and appropriate management strategy of chronic encapsulated expanding hematoma during pregnancy after gamma knife radiosurgery for arteriovenous malformation (AVM) remain unclear. CASE DESCRIPTION A 34-year-old female developed chronic encapsulated expanding hematoma during late pregnancy, after angiographic disappearance of cerebellar AVM following two courses of gamm...

The Leksell Gamma Knife is a standard radiosurgical tool for treating brain lesions by directing beams of gamma radiation to a specific region. The diameter of the gamma beams is confined by collimator systems and available collimator sizes are 4, 8, 14 and 18 mm. The reduction in dose rate for each collimator helmet is called the output factor (OPF). Experimental determination of OPFs is diffi...

Gamma knife radiosurgery is an effective alternative to embolization or microsurgical removal of small arteriovenous malformations, particularly in eloquent areas of brain tissue. Stereotaxic angiography is a useful diagnostic and targeting adjunct to gamma knife radiosurgery, and the authors present their experience (1,100 patients) with methods and technique, and show how the nidus of the art...

A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 ...

Background & Aim: The treatment of Parasagittal Meningioma (PSM) is always a challenge, especially when the tumor has already invaded the critical structures like venous sinuses. This study aims at evaluating the outcomes of Gamma Knife Radiosurgery (GKRS) in patients with PSM. Methods and Materials/Patients: In this descriptive retrospective study, we reviewed the medical records of 61 patien...