objective: to assess relative biological effectiveness (rbe) of 131i radiation relative to 60co gamma rays in glioblastoma spheroid cells. materials and methods: in this experimental study, glioblastoma spheroid cells were exposed to 131i radiation and 60co gamma rays. radiation induced dna damage was evaluated by alkaline comet assay. samples of spheroid cells were treated by radiation from 13...

Background: Hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems. Objective: In this article aims to investigate the radio-protective effect of hesperidin on the liver of Sprague Dawely rats. Material and Methods: In this clinical study, 40 male rats were selected randomly and divided into 8 ...

Introduction The Gamma Knife system is designed solely for non-invasive treatment of brain disorders, and it benefits from stereotactic surgical techniques. Dose calculations required in the system are performed by GammaPlan code; in this code, brain tissue is considered uniform. In the present study, we evaluated the effect of Gamma Knife system on the obtained dose through simulating a real ...

background: the study of rheological properties of blood has special interest since it is a circulating fluid exposed to shear rates during its life time. this work aims to investigate the influence of whole body gamma irradiation on the rheological properties of rat’s blood. the applied shear rate was from 12 to 375 s-1. low shear viscosity (up to 100 s-1) depends mainly on the erythrocytes ag...

background: the trabecular bone changes in the tibia of c3h/hen mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 gy) or 137cs-generated gamma-rays (0-6 gy). materials and methods: serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. tibiae were analyzed using microcomputed tomography. biomechanical...

Background: Recently, the Flattening Filter Free (FFF) beams, which allow a dose rate increase of up to four times compared to the normal dose rate, have been incorporated into radiation therapy machines. The aim of this study is to evaluate antitumor activity in hypoxic cells irradiated with different dose rates using FFF beams and to identify the casual mechanism for cellular damage during ir...

Background: During radiation therapy, stromal cells surrounding the tumor (e.g mesenchymal stem cells) may affect the treatment outcomes. We aimed to investigate the effects of gamma radiation on the mRNA expression of cytokines, DNA damage and population doubling time (PDT) of adipose-derived mesenchymal stem cells (ASCs). Material and methods: ASCs were enzymatically extracted from breast tis...

Background: Dosimetry is a fundamental part of the radiation processing industry. Aqueous inorganic dosimeters have been used for gamma radiation dosimetry such as standard ferrous sulfate dosimeter. The purpose of this study was to investigate the effect of gamma radiation on the diethyl fumarate DEF in dimethyl sulfoxide DMSO solution and its possible use in chemical dosimetry. Materials and ...

Introduction: The aim of this study was to investigate the initial electron beam parameters for Monte Carlo model of 6MV photon beam produced by Siemens Oncor® linear accelerator.   Materials and Methods: In this study, the EGSnrc Monte Carlo user codes BEAMnrc and DOSXYZnrc were used. The beamnrc code were used for modelling of a 6 MV photon beam produced by...