نتایج جستجو برای: gamma aminobutyric acid

تعداد نتایج: 846379  

2007
Melda YARDIMOGLU Gul ILBAY Sibel KOKTURK Funda Durmaz ONAR Deniz SAHIN Faruk ALKAN Hakki DALCIK

microscopy; kainic acid, (KA); lithium-pilocarpine, (LiPC); HS, hippocampal sclerosis; GABA, Gamma-aminobutyric acid; CNS, central nervous system; GER, granuler endoplasmic reticulum= rER, rough endoplasmic reticulum; DNA, deoksiribonucleic acid; RNA, ribonucleic acid; SE, status epilepticus; CA1, cornu ammons 1; CA2, cornu ammons 2; CA3, cornu ammons 3; GD, gyrus dentatus; DGC, dentate granule...

2017
Femke E Froklage Andrey Postnov Maqsood M Yaqub Esther Bakker Ronald Boellaard N Harry Hendrikse Emile FI Comans Robert C Schuit Patrick Schober Demetrios N Velis Jack Zwemmer Jan J Heimans Adriaan A Lammertsma Rob A Voskuyl Jaap C Reijneveld

Studies in rodents suggest that flumazenil is a P-glycoprotein substrate at the blood-brain barrier. This study aimed to assess whether [11C]flumazenil is a P-glycoprotein substrate in humans and to what extent increased P-glycoprotein function in epilepsy may confound interpretation of clinical [11C]flumazenil studies used to assess gamma-aminobutyric acid A receptors. Nine drug-resistant pati...

Journal: :Hypertension 2009
Julye M Adams Megan E Bardgett Sean D Stocker

Increased dietary salt enhances sympathoexcitatory and sympathoinhibitory responses evoked from the rostral ventrolateral medulla (RVLM). The purpose of the present study was to determine whether neurons of the forebrain lamina terminalis (LT) mediated these changes in the RVLM. Male Sprague-Dawley rats with and without LT lesions were fed normal chow and given access to water or 0.9% NaCl for ...

Journal: :Anesthesiology 2005
Ayako Wakai Tatsuro Kohno Tomohiro Yamakura Manabu Okamoto Toyofumi Ataka Hiroshi Baba

BACKGROUND Although isoflurane, a volatile anesthetic, can block the motor response to noxious stimulation (immobility and analgesia) and suppress autonomic responsiveness, how it exerts these effects at the neuronal level in the spinal cord is not fully understood. METHODS The effects of a clinically relevant concentration (1 rat minimum alveolar concentration [MAC]) of isoflurane on electri...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
T K Machu S J Mihic J E Dildy-Mayfield

Cytoclean a commercially available detergent, has selective actions on ligand-gated ion channels. Cytoclean (0.0005-0.01% v/v) potentiated 50 microM glycine responses in oocytes expressing alpha-2 glycine receptors by 23 +/- 7% to 342 +/- 43%. Cytoclean is composed of five components dissolved in water, but only one reagent, Bio-Soft D-62, modulated responses of oocytes expressing alpha-2 glyci...

Journal: :Journal of the American Chemical Society 2002
M del Pilar García-Santos Samuel González-Mancebo Jesús Hernández-Benito Emilio Calle Julio Casado

Nitrosation reactions of amino acids with an -NH(2) group [namely, six alpha-amino acids (glycine, alanine, alpha-aminobutyric acid, alpha-aminoisobutyric acid, valine, and norvaline); two beta-amino acids (beta-alanine and beta-aminobutyric acid), and one gamma-amino acid (gamma-aminobutyric acid)] were studied. Nitrosation was carried out in aqueous acid media, mimicking the conditions of the...

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