BACKGROUND AND PURPOSE Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and...

   In the present work, Gadolinium Doped ceria (GDC) based solid electrolyte was successfully synthesized through wet chemical method to operate at intermediate temperature (500–700°C) for SOFCs. DSC study revealed the formation of GDC phase at 900°C during calcination. The crystal structure of GDC was identified as cubic fluorite phase and the crystallite size was found to be around 23 nm....

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...

Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of gadolinium-containing contrast media which have reduced the number of new cases of NSF to almost zero. However, it i...

BACKGROUND AND PURPOSE Iron oxide-based contrast agents have been investigated as more specific MR imaging agents for central nervous system (CNS) inflammation. Ferumoxtran-10 is a virus-size nanoparticle, taken up by reactive cells, that allows visualization of the phagocytic components of CNS lesions. Ferumoxtran-10 was compared with standard gadolinium-enhanced MR images in this exploratory ...

SEE PAGE 1019 C ardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) (1) is the current clinical gold standard modality for evaluation of focal fibrosis and scar in patients with an ischemic or a nonischemic cardiomyopathy. LGE requires administration of an exogenous gadoliniumbased contrast agent, which accumulates in the scar region. LGE imaging is commonly performed using an inv...

The purpose of this study was to develop an in vivo imaging tool to monitor vascular gene transfer. We produced gadolinium/blue-dye and gadolinium/gene-vector media by mixing Magnevist with a trypan-blue or a lentiviral vector carrying a green fluorescent protein (GFP) gene. The gadolinium was used as an imaging marker for MRI to visualize vessel wall enhancement, while the blue-dye/GFP was use...

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...

In 2006, a connection was made between Gadolinium-based Contrast Agents (GBCAs) administered for contrast-enhanced MRIs and Nephrogenic Systemic Fibrosis (NSF). NSF is a potentially fatal disease that has been diagnosed almost exclusively in patients with end-stage renal disease (ESRD). Prolonged excretion times and the instability of the GBCA results in the toxic gadolinium ion separating from...